Tauroursodeoxycholic Acid Dihydrate CAS 14605-22-2 Assay 98.0~101.0%

Short Description:

Chemical Name: Tauroursodeoxycholic Acid Dihydrate

Synonyms: TUDCA 

CAS: 14605-22-2

Assay: 98.0~101.0% (Dried Base)

Appearance: White or Almost White Powder 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com  


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14605-22-2 - Description:

Ruifu Chemical is the leading manufacturer of Tauroursodeoxycholic Acid Dihydrate (TUDCA) (CAS: 14605-22-2) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Tauroursodeoxycholic Acid Dihydrate, Please contact: alvin@ruifuchem.com

14605-22-2 - Chemical Properties:

Chemical Name Tauroursodeoxycholic Acid Dihydrate 
Synonyms TUDCA; Tauroursodeoxycholic Acid; Tauroursodeoxycholic Acid, Sodium Salt; Sodium Tauroursodeoxycholate; 3α,7β-Dihydroxy-5β-Cholan-24-oic Acid N-(2-Sulfoethyl)amide Dihydrate; UR 906; TUDC Sodium Salt; Ursodoxicoltaurine; Tauroursodeoxycholate; 3α,7β-Dihydroxy-5β-Cholanoyltaurine;
Stock Status In Stock, Production Capacity 1000kgs per month
CAS Number 14605-22-2
Molecular Formula C26H45NO6S·2H2O
Molecular Weight 535.74 g/mol; 499.71 (Anhydrous Basis)
Melting Point 173.0~175.0℃ 
Density 1.216±0.06 g/cm3
Solubility in Hot Water  Almost Transparency  
COA & MSDS Available
Origin Shanghai, China
Brand Ruifu Chemical

14605-22-2 - Specifications:

Items Specifications Results
Appearance White or Almost White Powder  White Powder
Solubility Freely Soluble in Methanol and Ethanol.
Sparingly Soluble in Water.
Practically Insoluble in Ethyl Acetate and Acetone
Complies
Specific Rotation [a]20/D +45.0° to +47.0° (C=1 in Ethanol) +46.2° 
Mesh Size 90% Through 80 Mesh   Complies
Water by Karl Ficher 6.0~8.0% 7.0%
Sulphate Ash   ≤0.10% 0.05%
Taurine ≤0.20% Not Detected
Ursodeoxycholic Acid ≤0.50% <0.50%
Taurochenodeoxycholic Acid ≤1.00% 0.02%
Total Unspecified Impurities ≤0.50% 0.03%
Heavy Metals (Pb) ≤10ppm <10ppm
Arsenic Salt (As) ≤1.0ppm <1.0ppm
Microbiological Limit Test    
Total Plate Count ≤1000cfu/g <10cfu/g
Total Yeasts & Molds ≤100cfu/g <10cfu/g 
Salmonella Negative Negative
Escherichia Coli Negative Negative
Assay 98.0~101.0% (Dried Base) 99.61% 
Infrared Spectrum Comfroms to Structure Complies
Conclusion The product has been tested and complies with the given specifications
Shelf Life 2 Years When Properly Stored, and in Its' Original Package

Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Keep away from strong light, heat and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

14605-22-2 - Risk and Safety:

Safety Description S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
WGK Germany 2
RTECS KI7372500

14605-22-2 - Application:

Tauroursodeoxycholic Acid Dihydrate (TUDCA) (CAS: 14605-22-2) is an ambiphilic bile acid. is isolated from the bear bile of a natural bile acid, a chemical agent, in vivo and taurine in the presence of bile, is a hydrophilic cholic acid, as a cholesterol stone Dissolving agent.
Tauroursodeoxycholic Acid Dihydrate is the taurine conjugate form of Ursodeoxycholic Acid (UDCA). Humans are found to have trace amounts of TUDCA. Ongoing research is finding TUDCA has diminishing apoptotic effects, with potential application in heart disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke. Recently, TUDCA has been found to have protective effects in the eye, especially concerning retinal degenerative disorders.
TUDCA was found in bear bile in 1902, which is the main active ingredient of bear bile and the main ingredient of synthetic bear bile. It is widely found in human and a variety of animal bile. It has a variety of physiological and pharmacological effects. The drug and its preparations have been listed abroad for 20 years of clinical experience, mainly used for sterol gallbladder stones, cholestatic liver disease (such as: primary biliary cirrhosis), bile reflux gastritis, autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), chronic hepatitis (hepatitis B, hepatitis C, etc.), alcoholic fatty liver, non-alcoholic fatty liver, drug-induced liver damage, prevention and treatment of complications before and after liver transplantation.
Tauroursodeoxycholic Acid Dihydrate has antispasmodic, anticonvulsant, anti-inflammatory and gallstone-soluble effects. Biochemical research; Lipase accelerator; Anion remover, used for protein dissolution; Preparation of bacterial culture medium (intestinal bacteria culture and separation) Used for content determination/identification/pharmacological experiments, etc. 

14605-22-2 - Benefits:

Tauroursodeoxycholic Acid Dihydrate (TUDCA) (CAS: 14605-22-2)
1. TUDCA Can increase the secretion of bile acid.
2. TUDCA Reduce cholesterol in bile and cholesterol ester.
3. TUDCA Is conducive to the cholesterol gradually dissolve gallstones.
Noticed: TUDCA Should not be used for surgical treatment of cholesterol stone, it cannot dissolve the bile pigment stone, mixing and opaque X line of stones. 

14605-22-2 - Function:

1. Can reduce the secretion of cholesterol on the liver, lower cholesterol in the bile cholesterol, promote bile acid secretion, increase the solubility of cholesterol in the bile, the cholesterol stones dissolved or to prevent the formation of stones.
2. Can increase the amount of bile secretion, relaxation of the bile duct sphincter produce choleretic effect, is conducive to the discharge of stones.
3. It is suitable for the treatment of cholesterol-induced stones, hyperlipidemia, bile secretory diseases, primary biliary cirrhosis, chronic hepatitis, bile reflux gastritis and prevention of acute rejection and response to liver transplantation.
4. For the treatment of gallstones, primary sclerosing cholangitis, primary biliary cirrhosis and chronic hepatitis C virus. 

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