Ramelteon Acrylonitrile CAS 196597-79-2 Ramelteon Intermediate Purity >98.0% (HPLC)

Short Description:

Chemical Name: (E)-(1,6,7,8-Tetrahydro-2H-Indeno[5,4-b]furan-8-ylidene)acetonitrile

Synonyms: Ramelteon Acrylonitrile 

CAS: 196597-79-2

Purity: >98.0% (HPLC) 

Appearance: White to Yellow Solid Powder

Intermediate of Ramelteon (CAS: 196597-26-9)

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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196597-79-2 - Description:

Shanghai Ruifu Chemical is the leading supplier of Ramelteon Acrylonitrile (CAS: 196597-79-2) with high quality, mainly used as an intermediates of Ramelteon (CAS: 196597-26-9).
Ruifu Chemical has been supplying pharmaceutical intermediates and API (active pharmaceutical ingredient) more than 15 years, can provide worldwide delivery, competitive price, excellent service.
Purchase Ramelteon Acrylonitrile or other intermediates of Ramelteon, please e-mail: alvin@ruifuchem.com 

Intermediates of Ramelteon:

196597-79-2 - Chemical Properties:

Chemical Name (E)-(1,6,7,8-Tetrahydro-2H-Indeno[5,4-b]furan-8-ylidene)acetonitrile 
Synonyms Ramelteon Acrylonitrile; Ramelteon Impurity 6; Ramelteon Impurity B; Ramelteon Cyano Impurity; (E)-2-(6,7-Dihydro-1H-Indeno[5,4-b]furan-8(2H)-ylidene)acetonitrile; (2E)-2-(1,2,6,7-Tetrahydrocyclopenta[e][1]benzofuran-8-ylidene)acetonitrile; (1,2,6,7-Tetrahydro-3-oxa-as-indacen-8-ylidene)-acetonitrile 
CAS Number 196597-79-2
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C13H11NO
Molecular Weight 197.23 
Melting Point 146.0~151.0℃
Boiling Point 392.1±21.0℃ at 760 mmHg
Density 1.321±0.06 g/cm3
Solubility 10 mM in DMSO
Storage Condition 2-8℃
Shelf Life 24 Months When Properly Stored
COA & MSDS Available
Place of Origin  Shanghai, China
Product Categories Pharmaceutical Intermediates
Brand Ruifu Chemical

196597-79-2 - Specifications:

Item Specifications
Appearance White to Yellow Solid Powder
Purity / Analysis Method >98.0% (HPLC) 
Loss on Drying <1.00%
Total Impurities <2.00%
1 H NMR Spectrum Consistent With Structure  
Test Standard Enterprise Standard
Usage Intermediate of Ramelteon (CAS: 196597-26-9)

196597-79-2 - Package/Storage/Shipping:

Package: Bottle, aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry (2-8℃) and well-ventilated warehouse away from incompatible substances. Prevent direct sunlight; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by sea, by FedEx / DHL Express. Provide fast and reliable delivery. 

196597-79-2 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

196597-79-2 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

196597-79-2 - Application:

(E)-(1,6,7,8-Tetrahydro-2H-Indeno[5,4-b]furan-8-ylidene)acetonitrile (CAS: 935-56-8) is an intermediate of Ramelteon (CAS: 196597-26-9)Ramelteon (TAK-375) is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively. The melatonin molecule wasmodified mainly by replacing the nitrogen of the indole ringwith a carbon to give an indane ring and by incorporating 5-methoxyl group in the indole ring into a more rigid furan ring. The selectivity of the resulting ramelteon for MT1 receptor iseight times more than that of MT2 receptor. Unlike melatonin,it is more effective in initiating sleep (MT1 activity)rather than to readjust the circadian rhythm (MT2 activity). Itappears to be distinctly more efficacious than melatonin butless efficacious than benzodiazepines as a hypnotic. Importantly, this drug has no addiction liability (it is not acontrolled substance). As a result, it has recently been approvedfor the treatment of insomnia.

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