Ramelteon Intermediate CAS 196597-78-1 Purity >98.5% (HPLC)

Short Description:

Name: 1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-one

Synonyms: 6,7-Dihydro-1H-Indeno[5,4-b]furan-8(2H)-one

CAS: 196597-78-1

Purity: >98.5% (HPLC) 

Appearance: White to Pale Yellow Solid Powder

Intermediate of Ramelteon (CAS: 196597-26-9)

High Quality, Commercial Production

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Chemical Properties:

Chemical Name 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one 
Synonyms 6,7-Dihydro-1H-Indeno[5,4-b]furan-8(2H)-one; Ramelteon Intermediate 1; Ramelteon I
Impurity  Ramelteon Impurity A
CAS Number 196597-78-1 
CAT Number RF2883
Stock Status In Stock, Production Capacity 20 Tons per Month
Molecular Formula C11H10O2  
Molecular Weight 174.20  
Melting Point 133.0 to 137.0℃
Boiling Point 334.2±42.0℃
Density 1.288±0.06 g/cm3
Hazard Class  Irritant
Brand Ruifu Chemical


Item Specifications
Appearance White to Pale Yellow Solid Powder
Purity / Analysis Method >98.5% (HPLC) 
Melting Point 133.0 to 137.0℃
Water (by Karl Fischer) <0.50%
Residue on Ignition <0.10%
Total Impurities <1.50%
1 H NMR Spectrum Consistent With Structure  
Test Standard Enterprise Standard
Usage Intermediate of Ramelteon (CAS: 196597-26-9)

Package & Storage:

Package: Bottle, Aluminum foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture


Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system


How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 


1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one (CAS: 196597-78-1) is used as an intermediate of Ramelteon (CAS: 196597-26-9), the mother nucleus of synthesizing Ramelteon. Ramelteon is the first in a new class of sleep agents that selectively binds to the MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN), instead of binding to GABA receptors. Ramelteon does not show any appreciable binding to GABAA receptors, which are associated with anxiolytic, myorelaxant, and amnesic effects. Ramelteon can be used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse, and the withdrawal and rebound insomnia that is typical with GABA modulators is not present in ramelteon. Some clinicians also use ramelteon for the treatment of Delayed sleep phase syndrome. Treating insomnia (trouble falling asleep). It may also be used for other conditions as determined by your doctor. Ramelteon is a melatonin agonist. It works by acting on the melatonin receptors in the brain, which helps you fall asleep. 

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