Despropionyl Ramelteon Hydrochloride CAS 196597-80-5 Purity >98.0% (HPLC)

Short Description:

Chemical Name: (S)-2-(1,6,7,8-Tetrahydro-2H-Indeno[5,4-b]furan-8-yl)ethylamine Hydrochloride

Synonyms: Despropionyl Ramelteon Hydrochloride

CAS: 196597-80-5

Purity: >98.0% (HPLC)

Appearance: White to Off-White Solid Powder

Intermediate of Ramelteon (CAS: 196597-26-9)

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196597-80-5 - Description:

Shanghai Ruifu Chemical is the leading supplier of Despropionyl Ramelteon Hydrochloride (CAS: 196597-80-5) with high quality, mainly used as an intermediates of Ramelteon (CAS: 196597-26-9).
Ruifu Chemical has been supplying pharmaceutical intermediates and API (active pharmaceutical ingredient) more than 15 years, can provide worldwide delivery, competitive price, excellent service.
Purchase intermediates of Ramelteon, please e-mail: alvin@ruifuchem.com

Intermediates of Ramelteon:

Ramelteon (TAK-375)	CAS 196597-26-9
2,3-Dihydrobenzofuran	CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-one	CAS 196597-78-1
Ramelteon Acrylonitrile	CAS 196597-79-2
Despropionyl Ramelteon Hydrochloride	CAS 196597-80-5
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride	CAS 1053239-39-6

196597-80-5 - Chemical Properties:

Chemical Name	(S)-2-(1,6,7,8-Tetrahydro-2H-Indeno[5,4-b]furan-8-yl)ethylamine Hydrochloride
Synonyms	Despropionyl Ramelteon Hydrochloride; (S)-2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride; (S)-2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine HCl; Ramelteon Impurity 15 HCl; Ramelteon Amine Impurity
CAS Number	196597-80-5
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C13H17NO.HCl
Molecular Weight	239.74
Melting Point	270℃
Solubility in Water	Soluble in Chloroform, Dichloromethane, Ethyl Acetate, Methanol
Shelf Life	24 Months When Properly Stored
COA & MSDS	Available
Origin of Product	Shanghai, China
Product Categories	Pharmaceutical Intermediates
Brand	Ruifu Chemical

196597-80-5 - Specifications:

Item	Specifications
Appearance	White to Off-White Solid Powder
Purity / Analysis Method	>98.0% (HPLC)
Loss on Drying	<1.00%
Single Impurity	<1.00%
Total Impurities	<2.00%
1 H NMR Spectrum	Consistent With Structure
Test Standard	Enterprise Standard
Application	Intermediate of Ramelteon (CAS: 196597-26-9)

196597-80-5 - Package & Storage:

Package: Bottle, aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry (2-8℃) and well-ventilated warehouse away from incompatible substances. Prevent direct sunlight; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by sea, by FedEx / DHL Express. Provide fast and reliable delivery.

196597-80-5 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

196597-80-5 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

196597-80-5 - Application:

(S)-2-(1,6,7,8-Tetrahydro-2H-Indeno[5,4-b]furan-8-yl)ethylamine Hydrochloride, also known as Despropionyl Ramelteon Hydrochloride (CAS: 196597-80-5) is an intermediate of Ramelteon (CAS: 196597-26-9).
Ramelteon (TAK-375) is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively. The melatonin molecule wasmodified mainly by replacing the nitrogen of the indole ringwith a carbon to give an indane ring and by incorporating 5-methoxyl group in the indole ring into a more rigid furan ring. The selectivity of the resulting Ramelteon for MT1 receptor iseight times more than that of MT2 receptor. Unlike melatonin, it is more effective in initiating sleep (MT1 activity)rather than to readjust the circadian rhythm (MT2 activity). Itappears to be distinctly more efficacious than melatonin butless efficacious than benzodiazepines as a hypnotic. Importantly, this drug has no addiction liability (it is not acontrolled substance). As a result, it has recently been approvedfor the treatment of insomnia.