2,3-Dihydrobenzofuran CAS 496-16-2 Ramelteon Intermediate Purity >99.0% (GC) High Quality
Shanghai Ruifu Chemical is the leading supplier of 2,3-Dihydrobenzofuran (CAS: 496-16-2) with high quality, mainly used as an intermediates of Ramelteon (CAS: 196597-26-9).
Ruifu Chemical has been supplying pharmaceutical intermediates and API (active pharmaceutical ingredient) more than 15 years, can provide worldwide delivery, competitive price, excellent service.
Purchase 2,3-Dihydrobenzofuran other intermediates of Ramelteon, please e-mail: alvin@ruifuchem.com
| Chemical Name | 2,3-Dihydrobenzofuran |
| Synonyms | Coumaran; 2,3-Dihydro-2,3-Benzofuran; 2,3-Dihydrobenzo[b]furan; 2,3-Dihydro-1-Benzofuran |
| CAS Number | 496-16-2 |
| Stock Status | In Stock, Production Capacity 20 Tons per Month |
| Molecular Formula | C8H8O |
| Molecular Weight | 120.15 |
| Melting Point | -21℃ |
| Boiling Point | 188.0~189.0℃ (lit.) |
| Flash Point | 66℃ |
| Specific Gravity (20/20) | 1.09 |
| Refractive Index n20/D | 1.55 |
| Solubility | Alcohol: Soluble |
| Shelf Life | 24 Months When Properly Stored |
| COA & MSDS | Available |
| Place of Origin | Shanghai, China |
| Product Categories | Pharmaceutical Intermediates |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | Clear Colorless or Yellowish Liquid |
| Purity / Analysis Method | >99.0% (GC) |
| Water (by Karl Fischer) | <0.50% |
| Density (20℃) | 1.065~1.085 |
| Refractive Index n20/D | 1.547~1.551 |
| Single Impurity | <0.50% |
| Total Impurities | <1.00% |
| Proton NMR Spectrum | Conforms to Structure |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Ramelteon (CAS: 196597-26-9) |
Package: Fluorinated bottle, 25kg/drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry and well-ventilated warehouse away from incompatible substances. Prevent from direct sunlight; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by sea, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Symbols Xi - Irritant
Risk Codes 36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description S23 - Do not breathe vapour.
S24/25 - Avoid contact with skin and eyes.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany 3
TSCA Yes
HS Code 2932999099
Hazard Note Irritant
2,3-Dihydrobenzofuran (CAS: 496-16-2) is widely used in the synthesis of tricyclic compounds and is also an intermediate raw material for the synthesis of some important drugs.
2,3-Dihydrobenzofuran can be used as an intermediate of Ramelteon (CAS: 196597-26-9).
Ramelteon, marketed as Rozerem by Takeda Pharmaceuticals North America, is a sleep agent that selectively binds to the MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN), instead of binding to GABAA receptors, such as with drugs like zolpidem. It however does not appear to speed the onset of sleep or the amount of sleep a person gets. It is approved by the U.S. Food and Drug Administration (FDA) for long-term use. Ramelteon does not show any appreciable binding to GABAA receptors, which are associated with anxiolytic, myorelaxant, and amnesic effects. Unlike most treatments of insomnia that target the GABA (g-aminobutyric acid) receptor complex, ramelteon is an agonist of the melatonin receptor. In particular, it has high selectivity for the MT1 and MT2 subtypes, which have been implicated in the maintenance of circadian rhythms, over the MT3 receptor responsible for other melatonin functions.
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