2-(Trimethylsilyl)ethoxymethyl Chloride (SEM-Cl) CAS 76513-69-4 Purity >99.0% (GC)

2-(Trimethylsilyl)ethoxymethyl Chloride (SEM-Cl) (CAS: 76513-69-4) is an organosilicon compound that is used as a reagent in organic synthesis. SEM-Cl is used in a variety of applications, including the synthesis of polymers, pharmaceuticals, agrochemicals, pesticides, heterocycles, and other organosilicon compounds.
SEM-Cl is a reagent used in the protection of alcohols, secondary aryl amines, and imidazole, indole, and pyrrole nitrogens;electrophilic formaldehyde equivalent; acyl anion equivalent,used in One-carbon Homologations, Cyclizations etc.
SEM-Cl is a widely used reagent for the preparation protection groups for amines, alcohols, phenols, and carboxy groups. The nitrogen of amides and sulfonamides groups are also protected by using SEM-Cl reagent. SEM-Cl offers a versatile tool for selectively modifying specific functional groups.
SEM-Cl has been used in the synthesis of a variety of drugs, including antiretroviral drugs, anti-inflammatory drugs, and antiviral drugs.
In the synthesis of Ruxolitinib (CAS: 941678-49-5), SEM-Cl, as an important intermediate, plays an important role in the final quality and price of Ruxolitinib.
SEM-Cl, as a common silicone protective agent, but its price is expensive, not easy to preserve, purity is not high, has always been the concern of producers and users, is an urgent problem to be solved.