Chlorotrimethylsilane (TMCS) CAS 75-77-4 Purity >99.0% (GC) Factory

Short Description:

Chemical Name: Chlorotrimethylsilane

Trimethylchlorosilane; Trimethylsilyl Chloride; TMCS

CAS: 75-77-4

Purity: >99.0% (GC)

Appearance: Coloress Liquid

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Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Chlorotrimethylsilane (TMCS) (CAS: 75-77-4) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. Please contact:

Chemical Properties:

Chemical Name Chlorotrimethylsilane
Synonyms Trimethylchlorosilane; Trimethylsilyl Chloride; TMCS; TMS-Cl
CAS Number 75-77-4
CAT Number RF-PI2122
Stock Status In Stock, Production Capacity 350MT/Year 
Molecular Formula C3H9ClSi
Molecular Weight 108.64
Boiling Point  57℃(lit.) 
Sensitivity Moisture Sensitive
Hydrolytic Sensitivity 8: Reacts Rapidly with Moisture, Water, Protic Solvents
Solubility (Soluble in) Benzene, Ether, Perchloroethylene
Brand Ruifu Chemical


Item Specifications
Appearance Coloress Liquid
Purity / Analysis Method >99.0% (GC) 
Melting Point -40℃(lit.)
Density (20℃)  0.858~0.862
Refractive Index n20/D 1.385~1.390
Methyltrichlorosilane <0.50%
Total Impurities <1.00%
Infrared Spectrum Conforms to Structure
Test Standard Enterprise Standard

Package & Storage:

Package: Fluorinated Bottle, 25kg/Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture





Chlorotrimethylsilane (TMCS) (CAS: 75-77-4) is a valuable reagent for the protection of the hydroxyl function in organic synthesis. Chlorotrimethylsilane is a colorless fuming liquid with a pungent odor. Readily hydrolyzed with liberation of hydrogen chloride; soluble in benzene, ether and perchloroethylene. Chlorotrimethylsilane is a typical Silane Blocking Agent, which can protect or deprotect functional groups selectively. It is widely used in the syntheses of drugs. It have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis, and used for silylation and as a protection group in the process of various organic synthesis. Chlorotrimethylsilane is the most extensively used derivatization reagent for gas chromatography. The reactions are generally performed under anhydrous conditions although reactions can be performed on samples obtained from water-containing samples. There are considerable opportunities for artifacts stemming from a variety of reasons including off-target reactions with aldehydes and ketones. The rate of reaction of TMCS with nucleophilic targets is comparatively slow compared to other alkylsilyl chlorides and requires the presence of a base catalyst such as pyridine.

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