4,5-Dimethyl-1,3-Dioxol-2-One (DMDO) CAS 37830-90-3 Purity >99.0% (GC) Olmesartan Medoxomil Intermediate Factory

4,5-Dimethyl-1,3-Dioxol-2-One (DMDO) (CAS: 37830-90-3) is used in the preparation of Olmesartan Medoxomil (CAS: 144689-63-4). Olmesartan Medoxomil was launched in the US as Benicar@, an orally administered treatment for hypertension. Olmesartan, is a new selective and competitive nonpeptide angiotensin II type 1 receptor antagonist and potently inhibits the Ang.ll-induced pressor responses. The drug competitively inhibited binding of [125I1]-All to AT1 receptors in bovine adrenal cortical membranes, but had no effect on binding to AT2 receptors in bovine cerebellar membranes. In comparative clinical studies in patients with essential hypertension, Olmesartan reduced sitting cuff diastolic blood pressure significantly more than Losartan, Valdesartan and Ibesartan, while reductions in systolic blood pressure were similar for all treatments. Olmesartan Medoxomil was also shown to reduce blood pressure significantly more effectively than losartan and the ACE inhibitor captopril and as effectively as the pbloker atenolol.