TBTU CAS 125700-67-6 Purity >99.0% (HPLC) Factory Coupling Reagent for Peptide

Short Description:

Chemical Name: TBTU

CAS: 125700-67-6

Purity: >99.0% (HPLC)

Appearance: White Crystalline Powder

Coupling Reagent for Peptide Synthesis

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of TBTU (CAS: 125700-67-6) with high quality. Ruifu supplys a series of protecting reagents and coupling reagents. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase TBTU, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	O-(Benzotriazol-1-yl)-N,N,N',N'-Tetramethyluronium Tetrafluoroborate
Synonyms	TBTU; 1-[Bis(dimethylamino)methylene]-1H-Benzotriazolium 3-Oxide Tetrafluoroborate; N,N,N′,N′-Tetramethyl-O-(Benzotriazol-1-yl)uronium Tetrafluoroborate
Stock Status	In Stock, Mass Production
CAS Number	125700-67-6
Molecular Formula	C11H16BF4N5O
Molecular Weight	321.09 g/mol
Melting Point	200.0~208.0℃
Sensitive	Light Sensitive. Moisture Sensitive
Solubility	Soluble in Acetonitrile (100 mg/ml, Clear, Colorless), DMF (160.55 mg/ml, Clear), and Water (3 mg/ml at 20℃)
Storage Temp.	Cool & Dry Place (2~8℃)
COA & MSDS	Available
Category	Coupling Reagents
Brand	Ruifu Chemical

Specifications:

Items	Inspection Standards	Results
Appearance	White Crystalline Powder	Complies
Melting Point	200.0~208.0℃	206.4~207.3℃
Loss on Drying	<0.50%	0.06%
Heavy Metals (Pb)	≤20ppm	<20ppm
Purity / Analysis Method	>99.0% (HPLC)	99.8%
NMR Spectrum 1H	Conforms to Structure	Complies
Infrared Spectrum	Conforms to Structure	Complies
Conclusion	The product has been tested & complies with the given specifications

TBTU Test Conditions:

Solvent A: 0.1% TFA in CAN
Solvent B: 0.1% TFA in H2O
Gradient:      A       B
0.01min       5%      95%
20.00min      80%      20%
20.10min      100%      0%
25.00min            STOP
Flow Rate: 1.0ml/min
Sample Description: 5mg/10ml ACN:H2O=1:3
Volume: 10μL
Detection Wavelength: 220nm

Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Sensitive to light and moisture. Store under inert gas.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

125700-67-6 - Risk and Safety:

Risk Codes
R36/37/38 - Irritating to eyes, respiratory system and skin.
R5 - Heating may cause an explosion
R2 - Risk of explosion by shock, friction, fire or other sources of ignition
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S37/39 - Wear suitable gloves and eye/face protection
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S35 - This material and its container must be disposed of in a safe way.
UN IDs 1325
WGK Germany 3
FLUKA BRAND F CODES 8-10-21
Hazard Note Irritant/Flammable
Hazard Class 4.1
Packing Group Ⅱ

Application:

O-(Benzotriazol-1-yl)-N,N,N',N'-Tetramethyluronium Tetrafluoroborate (TBTU) (CAS: 125700-67-6) is used as coupling reagent for solid phase peptide synthesis.
An ideal solid-phase peptide synthesis coupling reagent; The crystal and Solution structure of the coupling reagent is guanidine Salt N-oxide, and not an uronium compound.
TBTU has been used to study ten different phosphonium and uronium salt-based coupling reagents, which are used to synthesize four peptides. TBTU has been documented as a coupling reagent to synthesize a tetrahydrocarbazole substituted dipeptide in a multi-gram solid-phase synthesis. The compound has also been incorporated with HOBt (hydroxybenzotriazole dihydrate) as a carboxyl activator before the coupling of a C-terminal amino acid with a success rate of 100% coupling.
TBTU is one of the most popular in situ activation reagents in solid and solution phase peptide synthesis. In addition to having high reactivity, TBTU have also been shown to limit enantiomerization during fragment condensation.