TCFH CAS 94790-35-9 Purity >99.0% (HPLC) Factory Coupling Reagents

Risk Codes
R36/37/38 - Irritating to eyes, respiratory system and skin.
R40 - Limited evidence of a carcinogenic effect
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S22 - Do not breathe dust.
WGK Germany 3
FLUKA BRAND F CODES 3-10-21

N,N,N',N'-Tetramethylchloroformamidinium Hexafluorophosphate (TCFH) (CAS: 94790-35-9), coupling reagent for peptide synthesis and starting material for preparing other coupling reagents. TCFH is a good non-hygroscopic peptide synthesis coupling reagent. As a general activation reagent of solid phase chemistry, TCFH mainly promotes the formation of carboxylic acid amine derivatives rather than amide in the coupling process of amino acids. It is very useful for the coupling of very hindered amino acids, and has the characteristics of simple and convenient synthesis process and long shelf life.
TCFH is a safe, affordable reagent for ester and difficult amide synthesis.
TCFH as a reagent has several advantages beside being economical:
– Due to is high coupling potency, it might be used in reactions previously only accomplished using carbodiimide-mediated couplings, extending in this manner its application for the formation of esters, diacyl amides and acylation of non-reactive amines
– It is solid, reasonably stable compound, when stored around 0°C
– Using the widely available coupling additives the chemist can find optimal reagent ratio to balance between the product yield and the side reactions including epimerization.