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(S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1 Ibrutinib Intermediate Purity >99.0% (GC) Featured Image
  • (S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1 Ibrutinib Intermediate Purity >99.0% (GC)
  • (S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1 Ibrutinib Intermediate Purity >99.0% (GC)
  • (S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1 Ibrutinib Intermediate Purity >99.0% (GC)

(S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1 Ibrutinib Intermediate Purity >99.0% (GC)

Short Description:

Chemical Name: (S)-1-Boc-3-Hydroxypiperidine

CAS: 143900-44-1

Chiral Purity: >99.0% (GC)

Chemical Purity: >99.0% (GC)

Appearance: White Powder or Crystals

Intermediate of Ibrutinib (CAS: 936563-96-1)

High Quality, Commercial Production

E-Mail: alvin@ruifuchem.com


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Description:

Ibrutinib CAS 936563-96-1                           
3-Hydroxypiperidine CAS 6859-99-0 
1-Boc-3-Hydroxypiperidine CAS 85275-45-2
(S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1
4-Phenoxybenzoic Acid  CAS 2215-77-2
4-Phenoxyphenylboronic Acid CAS 51067-38-0
4-Aminopyrazolo[3,4-d]pyrimidine CAS 2380-63-4
4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine  CAS 151266-23-8 
Ibrutinib Deacryloylpiperidine CAS 330786-24-8 
5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile CAS 330792-70-6

Chemical Properties:

Chemical Name (S)-1-Boc-3-Hydroxypiperidine
Synonyms (S)-N-Boc-3-Hydroxypiperidine; (S)-1-(tert-Butoxycarbonyl)-3-Hydroxypiperidine; (S)-1-Boc-3-Piperidinol; (S)-N-Boc-3-Piperidinol
CAS Number 143900-44-1
Stock Status In Stock, Production Capacity 20 Tons/Month
Molecular Formula C10H19NO3
Molecular Weight 201.27 
Melting Point  52.0~56.0℃
Flash Point 110℃(230°F)
Density 1.107±0.06 g/cm3
Solubility  Soluble in Methanol
Specific Rotation [a]20/D +9.0°~+11.0° (C=1 in Chloroform)
COA & MSDS Available
Origin Shanghai, China
Category   Pharmaceutical Intermediates
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance White Powder or Crystals
Chiral Purity >99.0% (GC)
Chemical Purity >99.0% (GC)
Water (K.F) ≤0.50%
Methanol (GC)  ≤50ppm
Ethanol (GC) ≤50ppm
DCM (GC) ≤500ppm 
3-Hydroxypiperidine ≤0.10%
3-Hydroxypyridine ≤0.20%
1-Boc-3-Piperidone ≤0.10%
1-Boc-4-Hydroxypiperidine ≤0.10%
1.96 RRT ≤0.20%
Any Unspecified Impurity ≤0.10%
Test Standard Enterprise Standard

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture. Incompatible with oxidizing agents. Stable under recommended storage conditions. 

Advantages:

1

FAQ:

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143900-44-1 - Application:

Hazard Symbols Xi - Irritant
Risk Codes 36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany 3

143900-44-1 - Application:

(S)-1-Boc-3-Hydroxypiperidine (CAS: 143900-44-1) is an important chiral intermediate for the synthesis of Ibrutinib (CAS: 936563-96-1). Ibrutinib is a kind of Bruton tyrosine kinase (BTK) inhibitor, it could be used for the treatment of chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). MCL and CLL are belonged to the B-cell non-Hodgkin's lymphoma, which is difficult to cure and easy to recurrent. Common chemical immunotherapy does not have the targeting, often occurs 3 or 4 adverse reactions. Ibrutinib and B lymphocytes could target with BTK which is necessary for formation, differentiation, and transmission of information, inhibit BTK activity irreversibly, and inhibit tumor cell proliferation and survival effectively. Ibrutinib could be rapidly absorbed after oral administration, during 1~2h reach maximum blood concentration, adverse reactions belong to one or two, therefore, Ibrutinib will become a new choice of treatment of CLL and MCL.

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