CDMT CAS 3140-73-6 2-Chloro-4,6-Dimethoxy-1,3,5-Triazine Purity >99.0% (HPLC)

1. Properties: This product is white crystalline powder.
2. Content determination:
2.1 Instruments and reagents: LC-10AVP Liquid Chromatograph, SPD-10AVP detector, Acetonitrile (chromatographic pure)
Trifluoroacetic acid (AR grade)
2.2 Procedure: According to high performance liquid chromatography (Chinese Pharmacopoeia 2010 edition Appendix VI D) determination.
2.3 Chromatographic conditions: octadecylsilane bonded silica gel was used as filler (250*4.6mm*5.0u); With acetonitrile:
Water = 60:40 (PH=2.5 adjusted by trifluoroacetic acid) was the mobile phase. The detection wavelength was 240nm. Column temperature: 25; flow
Speed: 1.0ml/min; The number of theoretical plates should not be less than 2000 according to the main peak of CDMT.
2.4 Determination method: This product was prepared into a mobile phase solution containing CDMT20ug per 1ml as the test product
The solution. 10ul of the test solution was injected into the chromatograph, and the chromatogram was recorded to 2 times the retention time of the principal component peak.
2.5 Results: This product was calculated by area normalization method and contained no less than 98.0% CDMT.
3. NMR characterization: frequency is 300MHz, with... Was a solvent, and the samples were characterized by H spectrum NMR at room temperature.
4. Melting point measurement:
4.1 Instrument
YRT-3 digital display melting point instrument and capillary for melting point determination (referred to as capillary).
4.2 Procedure
According to the method of melting point determination (Chinese Pharmacopoeia 2010 edition Appendix VII C).
4.3 Results
The melting point of this product is 71-78℃ (rate is 1.5℃/min).
5. Loss on Drying:
5.1 Instrument: vacuum drying oven flat weighing bottle
5.2 Operation procedure: Take 1g of this product, accurately weigh it, place it at 40.0℃ and dry it to constant weight.
5.3 Result: The weight loss shall not exceed 0.5%
5.4 Calculation: % = (Mass before drying - mass after drying)/ mass before drying * 100%
6. Storage: Store in a cool and dry place away from light (≤-20℃).
7. Reinspection period: one year