2-Acetyl-6-Methoxynaphthalene CAS 3900-45-6 Purity >99.0% (GC) Naproxen Nabumetone Intermediate

Short Description:

Chemical Name: 2-Acetyl-6-Methoxynaphthalene

Synonyms: 6′-Methoxy-2′-Acetonaphthone 

CAS: 3900-45-6

Purity: >99.0% (GC)

Appearance: Light Yellow or Almost White Crystal Powder

Intermediate in the Synthesis of Naproxen, Nabumetone 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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3900-45-6 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 2-Acetyl-6-Methoxynaphthalene (6'-Methoxy-2'-Acetonaphthone) (CAS: 3900-45-6) with high quality, intermediate in the synthesis of Naproxen (CAS: 22204-53-1) and Nabumetone (CAS: 42924-53-8). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Please contact: alvin@ruifuchem.com

Naproxen & Nabumetone Intermediates:

3900-45-6 - Chemical Properties:

Chemical Name 2-Acetyl-6-Methoxynaphthalene  
Synonyms 6'-Methoxy-2'-Acetonaphthone; 6-Methoxy-2-Acetylnaphthalene; 1-(6-Methoxy-2-Naphthyl)ethan-1-one; 1-(6-Methoxy-2-Naphehalenyl)ethanone; 1-(2-Methoxynaphthalen-6-yl)ethanone; 6-Acetyl-2-Methoxynaphthalene; 6-Methoxy-2-Acetylnaphthalene; NSC 105564
Impurity  Naproxen USP Related Compound L; Naproxen Impurity L
Stock Status In Stock, Production Capacity 500 Tons per Year
CAS Number 3900-45-6
Molecular Formula C13H12O2
Molecular Weight 200.24 g/mol
Melting Point 107.0 to 111.0℃ 
Boiling Point 195℃/12 mmHg 
Solubility  Soluble in Toluene
COA & MSDS Available
Origin of Product    China
Product Categories
Pharmaceutical Intermediates
Brand Ruifu Chemical

3900-45-6 - Specifications:

Items Specifications  Results
Appearance Light Yellow or Almost White Crystal Powder  Complies 
Melting Point 107.0 ~111.0℃ 107.0 ~109.0℃
Loss on Drying <0.30% 0.04%
1-Acetyl-2- Methoxynaphthalene <1.00% 0.02%
2-Methoxynaphthalene <0.50% 0.05%
Total Unknown Impurtities <0.50% 0.01%
2-Acetyl-6-Methoxynaphthalene  >99.0% (GC) 99.92%
Infrared Spectrum Consistent with Structure Complies
Conclusion The product has been tested and complies with the given specifications
Usage Intermediate of Naproxen (22204-53-1) & Nabumetone (42924-53-8) 

3900-45-6 - Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

3900-45-6 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

3900-45-6 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

3900-45-6 - Risk and Safety:

Hazard Symbols Xi - Irritant
Risk Codes R37/38 - Irritating to respiratory system and skin.
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description S37/39 - Wear suitable gloves and eye/face protection
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37 - Wear suitable protective clothing and gloves.
WGK Germany 3
HS Code 2914509090
Hazard Note Irritant

3900-45-6 - Application:

2-Acetyl-6-Methoxynaphthalene (6'-Methoxy-2'-Acetonaphthone) (CAS: 3900-45-6) is used as an important intermediate in the synthesis of Naproxen (CAS: 22204-53-1) and Nabumetone (CAS: 42924-53-8).
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Naproxen works by reducing hormones that cause inflammation and pain in the body. Naproxen is used to treat pain or inflammation caused by conditions such as arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, or menstrual cramps.
Nabumetone is an anti-inflammatory and antibacterial agent. A non-steroidal anti-inflammatory prodrug used for treatment of inflammatory and degenerative rheumatic diseases. Nabumetone is a non-acidic, non-ionic prodrug. After oral absorption, it is transformed into the main active product 6-methoxy-2-naphthaleneacetic acid (6-MNA) by the liver. Prostaglandin synthesis has anti-inflammatory, analgesic and antipyretic effects.  

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