Paxlovid Boceprevir Intermediate CAS 565456-77-1 Assay ≥99.0%

Short Description:

Name: (1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-Carboxylic Acid Methyl Ester Hydrochloride

CAS: 565456-77-1

Appearance: White to Off-White Powder 

Assay: ≥99.0%

Intermediate of PF-07321332 Paxlovid (CAS 2628280-40-8) and Boceprevir (CAS 394730-60-0) 

Contact: Dr. Alvin Huang 

Mobile/Wechat/WhatsApp: +86-15026746401  


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565456-77-1 - Chemical Properties:

Chemical Name (1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-Carboxylic Acid Methyl Ester Hydrochloride 
Synonyms Methyl (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate Hydrochloride; Boceprevir Intermediate 1
CAS Number 565456-77-1
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C9H15NO2.ClH
Molecular Weight 205.683
COA & MSDS Available
Place of Origin  Shanghai, China
Product Categories Pharmaceutical Intermediates
Caution Not Intended for Human or Veterinary Use. For Research Use Only.
Brand Ruifu Chemical

565456-77-1 - Specifications:

Item Specifications Results
Appearance White to Off-White Powder White Powder               
Identification A IR: Similar to Reference Substance Conforms          
Identification B Retention Time: Similar to Reference Substance Conforms
Enantiomer ≤0.15% 0.03%
Related Impurity (by HPLC)
Unknown Impurity ≤0.20% <0.20%
Total Impurities ≤1.00% 0.43%
Water by Karl Fischer ≤0.50% 0.26%
Residue on Ignition ≤0.10% 0.07%
Heavy Metals ≤20ppm <20ppm
Assay ≥99.0% 99.57%
Conclusion The product has been tested and complies with the given specifications
Usage Paxlovid (CAS 2628280-40-8) & Boceprevir (CAS 394730-60-0)

Package & Storage:

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture  




565456-77-1 - Application:

(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-Carboxylic Acid Methyl Ester Hydrochloride (CAS 565456-77-1) is an azabicyclohexane derivative used in the preparation of hepatitis C virus (HCV) NS3 serine protease inhibitor.  It's the intermediate of PF-07321332 Paxlovid (CAS 2628280-40-8) and Boceprevir (CAS 394730-60-0). PF-07321332 is a potent and orally active SARS-CoV 3C-like protease (3CLPRO) inhibitor . PF-07321332 targets to the SARS-CoV-2 virus and can be used for COVID-19 reseacrch. Boceprevir (INN, trade name Victrelis) is a protease inhibitor used as a treatment for hepatitis C genotype 1. It binds to HCV nonstructural 3 NS3 (HCV) active site. It was being developed by Schering-Plough, but is now being developed by Merck since Schering was acquired in 2009. It was approved by the FDA on May 13, 2011.

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