Olopatadine Hydrochloride Intermediate CAS 27710-82-3 Purity >99.0% (HPLC)
Leading Supplier of Olopatadine Hydrochloride Intermediates
Olopatadine Hydrochloride CAS 140462-76-6
Isoxepac CAS 55453-87-7
[3-(Dimethylamino)propyl]triphenylphosphonium Bromide Hydrobromide CAS 27710-82-3
Please Contact: alvin@ruifuchem.com
| Chemical Name | [3-(Dimethylamino)propyl]triphenylphosphonium Bromide Hydrobromide |
| Synonyms | (3-Dimethylaminopropyl)triphenylphosphonium Bromide HBr |
| CAS Number | 27710-82-3 |
| CAT Number | RF2698 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C23H28Br2NP |
| Molecular Weight | 509.27 |
| Melting Point | 283.0~285.0℃ |
| Stability | Hygroscopic |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White to Off-White Crystal Powder |
| Purity / Analysis Method | >99.0% (HPLC) |
| Assay / Analysis Method | >99.0% (Titration) |
| Loss on Drying | <0.50% |
| Single Impurity | <0.50% |
| Total Impurities | <1.00% |
| 1 H NMR Spectrum | Consistent With Structure |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Olopatadine Hydrochloride (CAS: 140462-76-6) |
Package: Bottle, Aluminum foil bag, 25kg/Cardboard Drum, or according to customer's requirement
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture
How to Purchase? Please contact: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Russia, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
[3-(Dimethylamino)propyl]triphenylphosphonium Bromide Hydrobromide (CAS: 27710-82-3) is an intermediate of Olopatadine Hydrochloride (CAS: 140462-76-6). Olopatadine Hydrochloride is an anti-allergic drug. It has the dual effects of inhibiting the release of histamine and selectively antagonizing HI receptors, and has no central nervous system inhibition and cardiac toxic side effects that are common with HI receptor antagonist antiallergic drugs. Olopatadine Hydrochloride can not only inhibit the release of histamine from mast cells, but also antagonize H1 receptors more selectively, and has no effect on α adrenergic receptors, dopamine receptors, and M1 and M2 receptors. Among them, the side effects of the central nervous system are few, is a new generation of antiallergic drugs of choice. Olopatadine is a potent, selective antagonist of the H1 histamine receptor (Ki = 16-41.1 nM), with much lower affinities for the H2 and H3 receptors (Ki = 43.4 and 172 μM, respectively). It blocks histamine-induced phosphoinositide turnover in isolated cells (IC50 = 9.5-39.9 nM) and prevents passive cutaneous anaphylaxis in rats (ED50 = 49 μg/kg) and anaphylactic bronchoconstriction in guinea pigs (ID50 = 30 μg/kg). Olopatadine is effective in treating allergic rhinitis and conjunctivitis. It also suppresses itch in patients with well-controlled chronic urticaria. In humans, this antihistamine does not cause cognitive or psychomotor impairment at therapeutic doses.
