Fulvestrant (ICI 182780) CAS 129453-61-8 API Factory High Quality

Short Description:

Name: Fulvestrant (ICI 182780)

CAS: 129453-61-8

Appearance: White to Off-White Crystalline Powder

Assay: 97.0%~102.0% (on dried basis)

Fulvestrant is used in the treatment of hormone-sensitive advanced breast cancer in postmenopausal women.

API High Quality, Commercial Production

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Product Detail

Product Tags

Description:

Manufacturer Supply with High Purity and Stable Quality
Name: Fulvestrant
CAS: 129453-61-8
Fulvestrant is used in the treatment of hormone-sensitive advanced breast cancer in postmenopausal women.
API High Quality, Commercial Production

Chemical Properties:

Chemical Name	Fulvestrant
Synonyms	(7α,17β)-7-[9-[(4,4,5,5,5-Pentafluorpentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3,17-diol; ICI 182780
CAS Number	129453-61-8
CAT Number	RF-API81
Stock Status	In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula	C32H47F5O3S
Molecular Weight	606.77
Melting Point	104.0~106.0℃
Solubility	Soluble in Methanol, Ethanol; Insoluble in Water
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	White to Off-White Crystalline Powder
Identification	By IR, HPLC
Specific Optical Rotation	+108.0° to +115.0°
Loss on Drying	≤0.50%
Residue on Ignition	≤0.10%
6-Keto-Fulvestrant	≤0.10%
6,7-Fulvestrant	≤0.10%
Fulvestrant Sulfone	≤0.20%
Fulvestrant Extended	≤0.30%
Fulvestrant Sterol Dimmer	≤0.80%
Any Individual Unspecified Impurity	≤0.10%
Total Impurities	≤1.0%
Fulvestrant A	42.0%~48.0%
Fulvestrant B	52.0%~58.0%
DMF	≤620ppm
Heavy Metals	≤10ppm
Assay	97.0%~102.0% (on dried basis)
Storage	Preserve in well-closed light-resistant containers store refrigerated at 2~8℃
Test Standard	United States Pharmacopoeia (USP) Standard
Usage	Estrogen Receptor Antagonist

Package & Storage:

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Advantages:

FAQ:

Application:

Fulvestrant (ICI-182780) CAS 129453-61-8, is a muscle injection drug developed by the company AstraZeneca and is used in the treatment of hormone-sensitive advanced breast cancer in postmenopausal women. Fulvestrant is the only antiestrogen drug that can be widely clinically used following unsuccessful tamoxifen treatment. This drug is a type of endocrine therapy, so it will not cause any adverse effects commonly seen in chemotherapy, giving it relatively good patient compliance. Multiple clinical trials have found that 250mg Fulvestrant is effective and consistently safe as a second line of treatment for advanced breast cancer. Fulvestrant is a synthetic Estrogen Receptor (ER) Antagonist with IC50 of 0.94 nM in a cell-free assay. Fulvestrant also induces autophagy and apoptosis and has antitumor activity.