Cl-HOBt CAS 26198-19-6 Purity >99.0% (HPLC) Factory Coupling Reagents

Short Description:

6-Chloro-1-Hydroxybenzotriazole Dihydrate

Synonyms: Cl-HOBT; 6-Cl-HOBt

CAS: 26198-19-6

Purity: >99.0% (HPLC)

Appearance: White Powder

Coupling Reagents, High Quality

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

26198-19-6 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 6-Chloro-1-Hydroxybenzotriazole Dihydrate (Cl-HOBT) (CAS: 26198-19-6) with high quality. Ruifu Chemical supplys a series of protecting reagents and coupling reagents. Ruifu can provide worldwide delivery, competitive price. Purchase Cl-HOBT or other products, Please contact: alvin@ruifuchem.com

26198-19-6 - Chemical Properties:

Chemical Name	6-Chloro-1-Hydroxybenzotriazole Dihydrate
Synonyms	Cl-HOBt; 6-Cl-HOBt; HOBt(6-Cl); 6-Chloro-1H-Benzotriazol-1-ol; 6-ChloroBenzotriazole-1-ol; 6-Chloro-1-Hydroxy-1H-Benzotriazole; 1-Hydroxy-6-Chlorobenzotriazole; 1-Hydroxy-6-Chloro-Benzotriazole; 6-Chloro-1H-benzo[d][1,2,3]triazol-1-ol
Stock Status	In Stock, Commercial Production
CAS Number	26198-19-6
Molecular Formula	C6H4ClN3O·2H2O
Molecular Weight	205.60 g/mol
Melting Point	193.0~200.0℃
Density	1.71±0.10 g/cm3
Storage Temp.	Cool & Dry Place (2~8℃)
COA & MSDS	Available
Category	Coupling Reagents
Brand	Ruifu Chemical

26198-19-6 - Specifications:

Items	Inspection Standards	Results
Appearance	White Powder	White Powder
Melting Point	193.0~200.0℃	194.9~195.8℃
Water by Karl Fischer	<10.0%	Complies
Purity / Analysis Method	>99.0% (HPLC)	99.9%
MS Spectrum	Conforms to Structure	Complies
NMR Spectrum	Conforms to Structure	Complies
Conclusion	The product has been tested & complies with the given specifications

26198-19-6 - Package/Storage/Shipping:

Package: Bottle, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery.
Caution: For safe storage and transport the material was desensitized with two equivalents of water.

26198-19-6 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

26198-19-6 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

26198-19-6 - Risk and Safety:

Risk Codes
R22 - Harmful if swallowed
R44 - Risk of explosion if heated under confinement
R36/37/38 - Irritating to eyes, respiratory system and skin.
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R2 - Risk of explosion by shock, friction, fire or other sources of ignition
Safety Description
S15 - Keep away from heat.
S36 - Wear suitable protective clothing.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S35 - This material and its container must be disposed of in a safe way.
UN IDs UN 1325 4.1/PG 2

26198-19-6 - Application:

6-Chloro-1-Hydroxybenzotriazole Dihydrate (Cl-HOBt; 6-Cl-HOBt) (CAS: 26198-19-6) is a reagent to suppress racemization in peptide coupling, which is not toxic. Reagent in peptide synthesis, has also been introduced into solid-phase synthesis.
6-Cl-HOBt is an alternative to HOBt. The chlorine atom attached to the ring increases the acidity and the effectiveness as a leaving group of 6-Cl-HOBt compared to HOBt. Like HOBt, 6-Cl-HOBt efficiently suppresses racemization during coupling. Cl-HOBt can be used in place of HOBt with equal or superior results. 6-Cl-HOBt increases the efficiency of carbodiimode mediated reactions by generating an active ester that prone for Amidation.
6-Cl-HOBt is a good compromise between HOAt and HOBt in terms of reactivity and price.