China OEM Hydroxylamine HCl - 2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0 Purity ≥99.5% (GC) Sitagliptin Phosphate Monohydrate Intermediate – Ruifu

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China OEM Hydroxylamine HCl - 2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0 Purity ≥99.5% (GC) Sitagliptin Phosphate Monohydrate Intermediate – Ruifu Detail:

Supply Sitagliptin Phosphate Monohydrate Related Intermediates:
Sitagliptin API CAS 486460-32-6
Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8
Sitagliptin Triazole Hydrochloride CAS 762240-92-6
Sitagliptin Phosphate Monohydrate Intermediate CAS 486460-21-3

Chemical Name	2,4,5-Trifluorophenylacetic Acid
CAS Number	209995-38-0
CAT Number	RF-PI1191
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C8H5F3O2
Molecular Weight	190.12
Melting Point	121.0 to 125.0℃
Solubility	Soluble in Methanol
Brand	Ruifu Chemical

Item	Specifications
Appearance	White to Off-White Powder
Purity / Analysis Method	≥99.5% (GC)
Moisture (K.F)	≤0.50%
Residue on Igniton	≤0.50%
Total Impurities	≤0.50%
Test Standard	Enterprise Standard
Usage	Intermediate of Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9)

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.

2,4,5-Trifluorophenylacetic Acid (CAS: 209995-38-0) is an intermediate of Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9). Sitagliptin Phosphate (STG) is used to treat DM type 2 because it improves glycemic control by increasing the levels of active incretin hormones, GLP-1 (peptide-1) and GIP (glucose-dependent insulinotropic peptide). The activation of these incretins in β-pancreatic cells causes increased levels of cyclic adenosine monophosphate (cAMP) and intracellular calcium, with subsequent glucose-dependent insulin secretion (2). This hypoglycemic drug belongs to a new class called dipeptidyl peptidase IV inhibitors. STG was approved by the FDA in 2006.

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