6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole CAS 84163-77-9 Risperidone Paliperidone Intermediate Purity >98.0% (HPLC)

Short Description:

6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole 

CAS: 84163-77-9

Purity: >98.0% (HPLC)

Appearance: White to Off-White Powder

Intermediate of Risperidone / Paliperidone 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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84163-77-9 - Description:

Ruifu Chemical is the leading manufacturer of 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole (CAS: 84163-77-9) with high quality. Ruifu can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Risperidone / Paliperidone Intermediates, Please contact: alvin@ruifuchem.com

Intermediates of Paliperidone:

84163-77-9 - Chemical Properties:

Chemical Name 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole 
Synonyms 6-Fluoro-3-(4-Piperidinyl)benzisoxazole; 4-(6-Fluoro-1,2-Benzisoxazol-3-yl)piperidine; 6-Fluoro-3-(Piperidin-4-yl)benzo[d]isoxazole; 4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidine
Stock Status In Stock, Commercial Production  
CAS Number 84163-77-9
Molecular Formula C12H13FN2O
Molecular Weight 220.25 g/mol
Melting Point 306℃ 
Density 1.216±0.06 g/cm3 
Sensitive Hygroscopic 
Solubility  Soluble in Methanol
COA & MSDS Available
Sample  Available
Origin Shanghai, China
Brand Ruifu Chemical

84163-77-9 - Specifications:

Items Specifications  Results
Appearance White to Off-White Powder  Complies      
Loss on Drying <0.50% 0.23% 
Purity / Analysis Method >98.0% (HPLC)  98.5% 
Infrared Spectrum Consistent with Structure Complies 
NMR Spectrum Consistent with Structure Complies
Conclusion The product has been tested and complies with the given specifications
Application: Intermediate of Risperidone (CAS: 106266-06-2) / Paliperidone (CAS: 144598-75-4)

Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

84163-77-9 - Risk and Safety:

Hazard Symbols T - Toxic
Risk Codes
R25 - Toxic if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
UN IDs UN 2811 6.1 / PGIII
WGK Germany 3
HS Code 2934999099
Hazard Class IRRITANT

84163-77-9 - Application:

6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole (CAS: 84163-77-9) is used as an intermediate of Risperidone (CAS: 106266-06-2) / Paliperidone (CAS: 144598-75-4).
Risperidone is a novel antipsychotic introduced for the treatment of acute and chronic schizophrenia. It has a balanced serotonin 5-HT2 and dopamine D2 receptor antagonist activity. For the treatment of schizophrenia in adults and in adolescents, ages 13 to 17, and for the short-term treatment of manic or mixed episodes of bipolar I disorder in children and adolescents ages 10 to 17. May also be used to manage symptoms of inappropria.
Paliperidone is the active metabolite of Risperidone, a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist. This medication is used to treat certain mental/mood disorders (such as schizophrenia, schizoaffective disorder). This medication can decrease hallucinations and help you to think more clearly and positively about yourself, feel less agitated, and take a more active part in everyday life. Paliperidone belongs to a class of drugs called atypical antipsychotics. It works by helping to restore the balance of certain natural substances in the brain. 

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