6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride CAS 84163-13-3 Risperidone Paliperidone Intermediate Purity >99.0% (HPLC)
Ruifu Chemical is the leading manufacturer of 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride (CAS: 84163-13-3) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Risperidone / Paliperidone Intermediates, Please contact: alvin@ruifuchem.com
Paliperidone CAS 144598-75-4
2-Amino-3-Benzyloxypyridine CAS 24016-03-3
6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole CAS 84163-77-9
6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride CAS 84163-13-3
3-(2-Chloroethyl)-6,7,8,9-Tetrahydro-9-Hydroxy-2-Methyl-4H-Pyrido[1,2-a]pyrimidin-4-one CAS 130049-82-0
| Chemical Name | 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride |
| Synonyms | 6-Fluoro-3-(Piperidin-4-yl)benzoisoxazole Hydrochloride; Paliperidone Int 2; 4-(6-Fluoro-1,2-Benzisoxazol-3-yl)piperidine Hydrochloride |
| Impurity | Risperidone EP Impurity M; Paliperidone USP Related Compound B |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 84163-13-3 |
| Alternate CAS | 84163-77-9 (Free Base) |
| Molecular Formula | C12H13FN2O·HCl |
| Molecular Weight | 256.71 g/mol |
| Melting Point | 293.0~295.0℃ |
| Density | 1.42g/cm3 at 20℃ |
| COA & MSDS | Available |
| Sample | Available |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | White to Off-White Powder | White Powder |
| Loss on Drying | <0.50% | 0.11% |
| Maximum Single Impurity | <0.50% | <0.50% |
| Total Impurities | <1.00% | <1.00% |
| Purity / Analysis Method | >99.0% (HPLC) | 99.2% |
| 1H NMR Spectrum | Consistent with Structure | Complies |
| LCMS | Consistent with Structure | Complies |
| Conclusion | The product has been tested and complies with the given specifications | |
| Application: Intermediate of Risperidone (CAS: 106266-06-2) / Paliperidone (CAS: 144598-75-4) | ||
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Statements
H315: Causes skin irritation.
H319: Causes serious eye irritation.
Precautionary Statements
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/ eye protection/ face protection.
P337 + P313: If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P362: Take off contaminated clothing and wash before reuse.
HS Number 2934.99.4400
6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride (CAS: 84163-13-3) is used as an intermediate of Risperidone (CAS: 106266-06-2) / Paliperidone (CAS: 144598-75-4).
Risperidone is used to treat acute and chronic schizophrenia and various other psychotic states with obvious positive symptoms (such as hallucinations, fantasies, thinking disorders, hostility, suspicion) and obvious negative symptoms (such as slow response, apathy and social apathy, lack of language). Risperidone can also reduce emotional symptoms related to schizophrenia (such as depression, guilt, anxiety). For patients with effective treatment in the acute phase, in the maintenance phase treatment, Risperidone can continue to exert its clinical efficacy.
Paliperidone is a dopamine and 5-HT2A antagonist that belongs to the class of atypical antipsychotics. Paliperidone is marketed by Janssen Pharmaceuticals as a controlled-release oral dosage form, which is taken once a day. The trade name is Invega, which is a drug using an osmotic pump-type controlled release system. Paliperidone (Invega) is an atypical antipsychotic. Chemically, paliperidone is the primary active metabolite of the older atypical antipsychotic risperidone. It is indicated for the acute and maintenance treatment of schizophrenia.
