Z-Thr-OMe CAS 57224-63-2 Z-L-Threonine Methyl Ester Purity ≥98.0% (HPLC)

Short Description:

Chemical Name: Z-L-Threonine Methyl Ester

Synonyms: Z-Thr-OMe

CAS: 57224-63-2

Purity: ≥98.0% (HPLC)

Appearance: White Powder

Contact: Dr. Alvin Huang

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E-Mail: alvin@ruifuchem.com

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Product Detail

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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Z-L-Threonine Methyl Ester (Z-Thr-OMe) (CAS: 57224-63-2) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Z-Thr-OMe, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	Z-L-Threonine Methyl Ester
Synonyms	Z-Thr-OMe; Z-L-Thr-OMe; N-Benzyloxycarbonyl-L-Threonine Methyl Ester; N-Carbobenzyloxy-L-Threonine Methyl Ester; Z-L-Threonine Methyl Ester; N-Cbz-L-Threonine Methyl Ester
Stock Status	In Stock
CAS Number	57224-63-2
Molecular Formula	C13H17NO5
Molecular Weight	267.28 g/mol
Melting Point	88.0~93.0℃
Sensitive	Air Sensitive
Water Solubility	Miscible in Water
Storage Temp.	Cool & Dry Place (2~8℃)
Shipping	Normal
COA & MSDS	Available
Brand	Ruifu Chemical

Safety Information:

Safety Statements	24/25 - Avoid contact with skin and eyes.
WGK Germany	3

Specifications:

Items	Inspection Standards	Results
Appearance	White Powder	White Powder
Melting Point	88.0~93.0℃	89.0~90.1℃
Specific Rotation	-18.0°±2.0° (C=1 in MeOH)	-18.9°
Water by Karl Fischer	<0.50%	0.26%
Purity / Analysis Method	≥98.0% (HPLC)	99.13%
Infrared Spectrum	Consistent with Structure	Complies
1 H NMR Spectrum	Consistent with Structure	Complies
Conclusion	The product has been tested & complies with the given specifications

Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

57224-63-2 - Application:

Z-L-Threonine Methyl Ester (Z-Thr-OMe) (CAS: 57224-63-2) can be used as intermediates in organic synthesis and pharmaceutical intermediates, used in peptide synthesis.

57224-63-2 - Preparation:

Add 70g L-threonine and ML methanol to a 1.1000ml three-necked flask, control the temperature below 0℃, 64 ml of thionyl chloride was added dropwise. After completion of the addition, the mixture was heated to reflux for 4 hours. Distillation under reduced pressure to dryness at 55℃. Gave 100g of L-threonine methyl ester hydrochloride as an oil. The next reaction was calculated with a yield of 100%; 2. In a 2L beaker, add 100g of L-threonine methyl ester hydrochloride, 600ml of water, and adjust the pH of sodium bicarbonate to alkaline, z-cl G was added dropwise and the pH was adjusted to 8-9 with 2MOC/l sodium hydroxide for reaction. At the end of the reaction, add ethyl acetate 1L to extract , take it, wash it with 500ml water, wash it with 500ml saturated brine, dry it with 100g anhydrous sodium sulfate, filter it with suction, distilled under reduced pressure until the solid precipitates, add petroleum ether 600Ml crystallization, Suction filtration, drying to obtain N-benzyloxycarbonyl-l-threonine methyl ester 140g, yield 89.1%.