Ivabradine Hydrochloride Intermediate CAS 866783-13-3 Purity >99.0% (HPLC) Assay 99.0%~100.5% (Titration)

Short Description:

Chemical Name: (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane Hydrochloride

CAS: 866783-13-3

Purity: >99.0% (HPLC) Assay: 99.0%~100.5% (Titration)

Appearance: White to Off-White Powder

Intermediate of Ivabradine Hydrochloride (CAS: 148849-67-6)

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Product Detail

Product Tags

Ivabradine Hydrochloride Intermediates:

Ruifu Chemical Supply Ivabradine Hydrochloride Intermediates With High Purity
Ivabradine Hydrochloride CAS 148849-67-6
4,5-Dimethoxy-1-Cyanobenzocyclobutane CAS 35202-54-1
(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane Hydrochloride CAS 866783-13-3
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one CAS 73942-87-7
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one CAS 148870-57-9
3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one CAS 85175-59-3

866783-13-3 - Chemical Properties:

Chemical Name	(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane Hydrochloride
Synonyms	Ivabradine Hydrochloride Intermediate; Intermediate of IVA 1; (1S)-4,5-Dimethoxy-1-(Methylaminomethyl)-Benzocyclobutane HCl; 3,4-Dimethoxy-N-Methyl-bicyclo[4.2.0]octa-1,3,5-triene-7-Methanamine Hydrochloride
CAS Number	866783-13-3
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C12H18ClNO2
Molecular Weight	243.73
Melting Point	>216℃(dec.)
COA & MSDS	Available
Shelf Life	>2 Years if Stored Properly
Place of Origin	Shanghai, China
Product Categories	Pharmaceutical Intermediates
Brand	Ruifu Chemical

866783-13-3 - Specifications:

Item	Specifications	Results
Appearance	White to Off-White Powder	White Powder
Identification	A, UV	Complies
Identification	B, HPLC	Complies
Specific Rotation	+14.0° ~ +19.0° (1% solution in methanol)	+15.26°
Loss on Drying	<0.50% (Dry it at 105℃ in vacuum till a constant weight)	0.17%
Individual Impurity	<0.50%	0.005%
Optical Isomers	<0.50%	0.005%
Chromatographic Purity	>99.0% (% area normalization, by HPLC)	99.99%
Assay	99.0%~100.5% (on dried basis, by Titration)	100.5%
Conclusion	The product has been tested and complies with the given specifications
Application	Intermediate of Ivabradine Hydrochloride (CAS: 148849-67-6)

866783-13-3 - Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

FAQ:

866783-13-3 - Application:

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane Hydrochloride (CAS: 866783-13-3) is an intermediate used in preparation of Ivabradine Hydrochloride (CAS: 148849-67-6) which is a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Ivabradine reduces the speed of diastolic depolarization and decreases heart rate. Ivabradine Hydrochloride has been approved for the treatment of chronic stable angina and provides a viable alternative to patients with a contraindication or intolerance of b-blockers. Evaluation is also underway for the potential treatment of ischemic heart disease.