Sodium 4-Aminosalicylate CAS 133-10-8 Purity >99.0% (HPLC)

Sodium 4-Aminosalicylate (CAS: 133-10-8) is easily soluble in water, slightly soluble in ethanol, insoluble in acetone. It can be used as anti-tuberculosis drugs, mainly for the comprehensive treatment of tuberculosis infection. This product is similar to 4-Aminobenzoic acid (PABA) in structure, is a congener of PABA. It inhibits the growth and reproduction of Mycobacterium tuberculosis by competitive inhibition of folate synthesis. This product is only effective against mycobacteria, not atypical mycobacteria. When used alone, can rapidly develop drug resistance. This product must be combined with other anti-tuberculosis drugs, such as streptomycin and isoniazid, which can delay the production of drug resistance of tuberculosis bacilli to the latter two. Clinically, it is mainly used for pulmonary and extrapulmonary tuberculosis caused by Mycobacterium tuberculosis. It is also used in hyperthyroidism and has a strong effect on lowering blood lipids. Well absorbed from the GI tract. More rapidly absorbed than other salicylic acids. After absorption, it is rapidly distributed in various body fluids and reaches a very high concentration in pleural fluid, but the concentration in cerebrospinal fluid is very low. The product rapidly diffuses into kidney, lung and liver tissues, reaching higher concentrations in caseous tissues. It is suitable for pulmonary and extrapulmonary tuberculosis caused by Mycobacterium tuberculosis. Sodium para-aminosalicylate is effective only against mycobacteria and not against nontuberculous mycobacteria. Resistance can develop rapidly when used alone, so it must be combined with other anti-TB drugs. Streptomycin and isoniazid, when combined with them, can delay the development of drug resistance of Mycobacterium tuberculosis to the two drugs. It is mainly used as a second-line anti-tuberculosis drug. It can also be used for hyperthyroidism, and it is more suitable for patients with hyperthyroidism and tuberculosis. When the iodine agent is ineffective and affects the operation, it can be taken for a short period of time to create conditions for the operation. Intravenous infusion is generally used in severe cases such as tuberculous meningitis.