SMCC CAS 64987-85-5 Purity >99.0% (HPLC) Protein Crosslinker Factory
Ruifu Chemical is the leading manufacturer of N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate (SMCC) (CAS: 64987-85-5) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase SMCC, Please contact: alvin@ruifuchem.com
| Chemical Name | N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate |
| Synonyms | SMCC; SMCC Crosslinker; 4-(Maleimidomethyl)cyclohexane-1-Carboxylic Acid N-Hydroxysuccinimide Ester; N-Succinimidyl 4-(Maleimidomethyl) cyclohexane-1-Carboxylate; 4-(N-Maleimidomethyl)cyclohexanecarboxylic Acid N-Succinimidyl Ester; Succinimidyl- trans-4-(N-Maleimidylmethyl)cyclohexane-1-Carboxylate; 2,5-Dioxopyrrolidin-1-yl 4-[(2,5-Dioxo-2,5-dihydro-1H-Pyrrol-1-yl)methyl]cyclohexane-1-Carboxylate |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 64987-85-5 |
| Molecular Formula | C16H18N2O6 |
| Molecular Weight | 334.33 g/mol |
| Melting Point | 165.0~179.0℃ |
| Density | 1.42±0.10 g/cm3 |
| Store Under Inert Gas | Store Under Inert Gas |
| Sensitive | Light Sensitive, Moisture Sensitive, Heat Sensitive |
| COA & MSDS | Available |
| Shelf Life | >2 Years if Stored Properly |
| Place of Origin | Shanghai, China |
| Product Categories |
Protein Crosslinkers; Bioconjugation Reagents |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | White to Off-White Crystalline Powder | Complies |
| Melting Point | 165.0~179.0℃ | 175.0~176.3℃ |
| Loss on Drying | <0.50% | 0.11% |
| Solution Test (in DMF) | Clear & Transparent | Clear & Transparent |
| Infrared Spectrum | Consistent with Structure | Complies |
| Conclusion | The product has been tested and complies with the given specifications | |
| Attention | Protect from the light and store in a cool and dry place. (2~8℃) | |
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Keep away from light; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
Column: SHIMDZU VP-ODS (250mmL*4.6mm i.d.)
The Octadecylsilane bonded silica gel was used as filler (250*4.6mm 5.0μ);
The mobile phase was acetonitrile: water (PH=3.5 trifluoroacetic acid aqueous solution) = 70:30.
The detection wavelength was at 220nm
Column temperature was 25℃
Flow rate: 1.0ml/min
The theoretical number of plates should not be less than 2000 according to the main peak of SMCC.
Determination method: Take this product and prepare a mobile phase solution containing SMCC 50μg in each 1ml as the test product solution. Sample solution 10μl was injected into the chromatograph and the chromatogram was recorded for 20 minutes.
Results: The results were calculated by area normalization method with SMCC no less than 99.0%.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Symbols Xi - Irritant
Risk Codes 36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S60 - This material and its container must be disposed of as hazardous waste.
S37 - Wear suitable gloves.
WGK Germany 3
FLUKA BRAND F CODES 10-21
HS Code 2928000090
N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate (SMCC) (CAS: 64987-85-5) is a hetero-bifunctional crosslinker that contain N-Hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. SMCC crosslinker must be dissolved in an organic solvent, such as DMSO or DMF, and then can be added to an aqueous crosslinking reaction. SMCC crosslinking reagent is permeable across the lipid bilayer of the cell membrane and can be used to crosslink intracellular proteins and peptides. A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent.
SMCC is a non-cleavable and membrane permeable crosslinker. It contains an amine-reactive N -hydroxysuccinimide (NHS ester) and a sulfhydryl-reactive maleimide group. NHS esters react with primary amines at pH 7-9 to form stable amide bonds. Maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. The maleimide groups of SMCC and Sulfo-SMCC and are unusually stable up to pH 7.5 because of the cyclohexane bridge in the spacer arm.
The company's self-developed protein crosslinker products SMCC (CAS: 64987-85-5) and Sulfo-SMCC (CAS: 92921-24-9) can be used for the synthesis of Kadcyla and Trodelvy. With the rise of global ADC drugs, the market demand for protein crosslinker will also increase rapidly.
