(S)-(-)-N,N-Dimethyl-3-Hydroxy-3-(2-Thienyl)propanamine CAS 132335-44-5 Purity >99.0% (GC) Duloxetine Hydrochloride Intermediate Factory
Manufacturer Supply, High Quality, Commercial Production
Chemical Name: (S)-(-)-N,N-Dimethyl-3-Hydroxy-3-(2-Thienyl)propanamine
CAS: 132335-44-5
| Chemical Name | (S)-(-)-N,N-Dimethyl-3-Hydroxy-3-(2-Thienyl)propanamine |
| Synonyms | (S)-3-(Dimethylamino)-1-(2-Thienyl)-1-Propanol; (S)-2-[3-(Dimethylamino)-1-Hydroxypropyl]thiophene; Duloxetine Intermediate AA |
| CAS Number | 132335-44-5 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C9H15NOS |
| Molecular Weight | 185.29 |
| Melting Point | 77.0~80.0℃ |
| Boling Point | 290℃ |
| Flash Point | 129℃ |
| Density | 1.111 |
| Specific Rotation [a]20/D | -4.0° to -8.0° (C=1, Methanol) |
| Solubility | Soluble in Methanol |
| COA & MSDS | Available |
| Place of Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White Powder |
| Purity / Analysis Method | >99.0% (GC) |
| Moisture (K.F) | <0.50% |
| (S)-3-(Dimethylamino)-1-(Thiophen-3-yl)propan-1-ol | <0.05% |
| Single Impurity | ≤ 0.20% |
| R-Isomer | <0.50% |
| Total Impurities | <0.50% |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Duloxetine Hydrochloride (CAS: 136434-34-9) |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.
Risk Codes
36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
HS Code 2934999099
(S)-(-)-N,N-Dimethyl-3-Hydroxy-3-(2-Thienyl)propanamine (CAS: 132335-44-5) is a key intermediate of Duloxetine Hydrochloride (CAS: 136434-34-9). Duloxetine Hydrochloride is used for the treatment of depression, was successfully developed by Eli Lilly Company. Duloxetine hydrochloride is a new kind of selective dual inhibitor of 5 hydroxy trptamine (5-HT) and norepinephrine reuptake, and thus having antidepressant effect, while also having inhibitory effect on the central pain. Its pharmacological characteristic is being able to inhibit neuronal pre-synaptic membrane’s reuptake on 5-hydroxy trptamine and norepinephrine but instead have a low inhibitory effect on the reuptake of dopamine. Duloxetine hydrochloride is indicated for depression and it is effective in treating both endogenous and non-endogenous depression as well as the feeling of pain associated with depression.
