Nicotinamide CAS 98-92-0 Assay 99.0%-101.0% High Purity

Short Description:

Chemical Name: Nicotinamide

CAS: 98-92-0

Assay: 99.0%-101.0% (Titration) (Dried Substance)

Appearance: White or Almost White Crystalline Powder

Production Capacity 8000 Tons per Year, High Purity

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401


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98-92-0 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Nicotinamide (CAS: 98-92-0) with high quality, production capacity 8000 tons per year. Ruifu Chemical has been supplying Nicotinamide more than 15 years.
Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase Nicotinamide, please contact us by e-mail:

98-92-0 - Chemical Properties:

Chemical Name Nicotinamide
Synonyms Niacinamide; Nicotinic Acid Amide; VB3; VPP; Vitamin PP; Vitamin B3; Niacin; Pyridine-3-Carboxamide; 3-Pyridinecarboxyamide; Pyridine-3-Carboxylic Acid Amide
Stock Status In Stock, Production Capacity 8000 Tons per Year
CAS Number 98-92-0
Molecular Formula C6H6N2O
Molecular Weight 122.13 g/mol
Melting Point 128.0 to 131.0℃ 
Density 1.40 g/cm3 
Sensitive Light Sensitive 
Water Solubility  Soluble in Water (Almost Transparency 1000 g/l 20℃)
Stability Stable. Incompatible with Strong Oxidizing Agents 
Storage Temperature Store Long-Term in a Cool and Dry Place 
Shelf Life   2 Years When Properly Stored 
Quality Standard USP EP BP JP
COA & MSDS Available
Sample  Available
Origin of Product    Shanghai, China
Product Categories
Pharmaceutical Intermediates
Caution Research Use Only and Are Not Intended for Human Use 
Brand Ruifu Chemical

98-92-0 - Specifications:

Items Specifications  Results
Appearance White or Almost White Crystalline Powder   White Crystalline Powder
Infrared Spectrum Conforms to Structure   Conforms 
Appearance of Solution Clear and Not More Intensely Coloured
Than Reference Solution BY7
pH 6.0-7.5 (10% Aqueous Solution) 6.5
Melting Point 128.0-131.0℃ 128.9-129.2℃
Loss on Drying ≤0.50% 0.05%
Sulfated Ash  ≤0.10% 0.06%
Heavy Metals (Pb) ≤20ppm <10ppm 
Assay / Analysis Method 99.0%-101.0% (Titration) (Dried Substance)  99.9%
Conclusion The product has been tested and complies with the given specifications

98-92-0 - Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry and well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

98-92-0 - European Pharmacopoeia 11.0:

C6H6N2O 122.1 [98-92-0]
Content: 99.0 per cent to 101.0 per cent (dried substance).
Appearance: white or almost white, crystalline powder or colourless crystals.
Solubility: freely soluble in water and in anhydrous ethanol, slightly soluble in methylene chloride.
First identification: B.
Second identification: A, C.
A. Melting point (2.2.14): 128℃ to 131℃.
B. Infrared absorption spectrophotometry (2.2.24).
Comparison: Nicotinamide CRS.
C. Thin-layer chromatography (2.2.27).
Test solution. Dissolve 5 mg of the substance to be examined in a mixture of equal volumes of ethanol (96 per cent) R and water R and dilute to 5.0 mL with the same mixture of solvents.
Reference solution. Dissolve 5 mg of nicotinamide CRS in a mixture of equal volumes of ethanol (96 per cent) R and water R and dilute to 5.0 mL with the same mixture of solvents.
Plate: TLC silica gel F254 plate R.
Mobile phase: water R, ethanol (96 per cent) R, methylene chloride R (4:45:48 V/V/V).
Application: 5 μL.
Development: over 2/3 of the plate.
Drying: in air.
Detection: examine in ultraviolet light at 254 nm.
Results: the principal spot in the chromatogram obtained with the test solution is similar in position and size to the spot in the chromatogram obtained with the reference solution.
Solution S. Dissolve 2.5 g in carbon dioxide-free water R and dilute to 50 mL with the same solvent.
Appearance of solution. Solution S is clear (2.2.1) and not more intensely coloured than reference solution BY7 (2.2.2, Method II).
pH (2.2.3): 6.0 to 7.5 for solution S.
Related substances. Liquid chromatography (2.2.29).
Test solution. Dissolve 0.150 g of the substance to be examined in mobile phase A and dilute to 150.0 mL with mobile phase A.
Reference solution (a). Dilute 1.0 mL of the test solution to 100.0 mL with mobile phase A. Dilute 1.0 mL of this solution to 10.0 mL with mobile phase A.
Reference solution (b). Dissolve 5 mg of isonicotinamide R (impurity D) in the test solution and dilute to 100.0 mL with the test solution. Dilute 1.0 mL of this solution to 25.0 mL with the test solution.
- size: l = 0.15 m, Ø = 4.6 mm;
- stationary phase: base-deactivated end-capped octadecylsilyl
silica gel for chromatography R (3 μm).
Mobile phase :
- mobile phase A: mix 5.0 mL of dilute acetic acid R and 900 mL of water for chromatography R, then add 30 mL of dilute ammonia R3 and 15 mL of acetonitrile R; dilute to 1 L with water for chromatography R;
- mobile phase B: acetonitrile R, mobile phase A (50:50 V/V);
Time (min) Mobile phase A (per cent V/V) Mobile phase B
(per cent V/V)
0 - 2 98 2
2 - 16 98 → 0 2 → 100
Flow rate: 1.0 mL/min.
Detection: spectrophotometer at 264 nm.
Injection: 20 μL.
Identification of impurities: use the chromatogram obtained with reference solution (b) to identify the peak due to impurity D.
Relative retention with reference to Nicotinamide (retention time = about 7 min): impurity D = about 0.9.
System suitability: reference solution (b):
- resolution: minimum 2.0 between the peaks due to impurity D and Nicotinamide.
Calculation of percentage contents:
- for each impurity, use the concentration of Nicotinamide in reference solution (a).
- unspecified impurities: for each impurity, maximum 0.10 per cent;
- total: maximum 0.2 per cent;
- reporting threshold: 0.05 per cent.
Loss on drying (2.2.32): maximum 0.5 per cent, determined on 1.000 g by drying in vacuo for 18 h.
Sulfated ash (2.4.14): maximum 0.1 per cent, determined on 1.0 g.
Dissolve 0.100 g in 50 mL of anhydrous acetic acid R. Titrate with 0.1 M perchloric acid, determining the end-point potentiometrically (2.2.20). 1 mL of 0.1 M perchloric acid is equivalent to 12.21 mg of C6H6N2O.
Other detectable impurities (the following substances would, if present at a sufficient level, be detected by one or other of the tests in the monograph. They are limited by the general acceptance criterion for other/unspecified impurities and/or by the general monograph Substances for pharmaceutical use (2034). It is therefore not necessary to identify these impurities for demonstration of compliance. See also 5.10. Control of impurities in substances for pharmaceutical use): A, B, C, D, E.
A. pyridine-3-carboxylic acid (nicotinic acid),
B. pyridine-3-carbonitrile,
C. pyridine-2-carboxamide (picolinamide),
D. pyridine-4-carboxamide (isonicotinamide),
E. pyridine-3-carboxamide 1-oxide (nicotinamide N-oxide).

98-92-0 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

98-92-0 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: or 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

98-92-0 - Risk and Safety:

Risk Codes
R36/37/38 - Irritating to eyes, respiratory system and skin.
R39/23/24/25 -
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed.
R11 - Highly Flammable
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S37/39 - Wear suitable gloves and eye/face protection
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37 - Wear suitable protective clothing and gloves.
S16 - Keep away from sources of ignition.
S7 - Keep container tightly closed.
UN IDs UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 1
RTECS QS3675000
HS Code 2936290000

98-92-0 - Application:

Nicotinamide (CAS: 98-92-0) is a water-soluble vitamin and a very important member of the B group of vitamins. Nicotinamide is the amide of Nicotinic Acid (Vitamin B3 / Niacin). If the human body lacks vitamin B3, symptoms such as rough skin, weight loss, diarrhea, insomnia, forgetfulness, and depression will occur. The function of B3 is to maintain the normal function of the human skin and has the function of beauty and skincare.
The first effect can inhibit the production of melanin and have a whitening effect. Vitamin B 3 not only inhibits the production of melanin, but also reduces melanin. The second effect vitamin B3 can accelerate the metabolism of the human skin, promote blood circulation, reduce melanin on the skin surface, and restore damaged cells, making the skin appear youthful. The third function is to promote the growth of proteins on the surface of the skin.
The lack of Nicotinamide in the body will cause pellagra, so this product can prevent pellagra. Nicotinamide plays a role in the metabolism of protein and sugar and improves nutrition in humans and animals.
Nicotinamide can be used as nutritional additive in cosmetics. It has an effective whitening function. As a cosmetics ingredient, Nicotinamide is widely applied in skin and hair care products. In addition, Nicotinamide is also used in medicine and food and feed additives.

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