HMBA Linker CAS 3006-96-0 4-(Hydroxymethyl)benzoic Acid Purity >99.0% (HPLC)

Short Description:

4-(Hydroxymethyl)benzoic Acid

Synonyms: HMBA Linker 

CAS: 3006-96-0

Purity: >99.0% (HPLC)

Appearance: White Crystalline Powder

Linkers for Solid Phase Synthesis

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401


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Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 4-(Hydroxymethyl)benzoic Acid (HMBA Linker) (CAS: 3006-96-0) with high quality. Ruifu Chemical supplys a series of linkers for solid phase synthesis. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase HMBA Linker, Please contact:

Chemical Properties:

Chemical Name 4-(Hydroxymethyl)benzoic Acid 
Synonyms HMBA Linker; 4-Hydroxymethylbenzoic Acid; p-(Hydroxymethyl)benzoic Acid; 4-Carboxybenzyl Alcohol; p-Carboxybenzyl Alcohol; HB Linker
Stock Status In Stock, Commerical Scale
CAS Number 3006-96-0
Molecular Formula C8H8O3
Molecular Weight 152.15 g/mol
Melting Point 182.0~185.0℃(lit.) 
Density 1.314±0.06 g/cm3 
Solubility in Hot Methanol  Almost Transparency 
Storage Temp.  Cool & Dry Place (2~8℃) 
COA & MSDS Available
Category   Linkers for Solid Phase Synthesis 
Brand Ruifu Chemical


Items Inspection Standards Results
Appearance White Crystalline Powder  Complies      
Melting Point 182.0~185.0℃ Complies 
Loss on Drying <1.00% 0.23% 
Purity / Analysis Method >99.0% (HPLC)  99.8% 
Purity (Titration by NaOH)  98.5~101.5% Complies
Infrared Spectrum Conforms to Structure Complies      
1 H NMR Spectrum  Conforms to Structure Complies      
Conclusion The product has been tested & complies with the specifications


Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery. 


Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system


How to Purchase? Please contact Dr. Alvin Huang: or 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

3006-96-0 - Risk and Safety:

Hazard Symbols Xi - Irritant
Risk Codes
36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S37/39 - Wear suitable gloves and eye/face protection
WGK Germany 3
HS Code 2916310000


4-(Hydroxymethyl)benzoic Acid (HMBA Linker) (CAS: 3006-96-0), linkers for solid phase synthesis, reagent type: cross-linking reagent. Linker for solid-phase peptide synthesis, stable to TFA but cleaved by nucleophiles.
This linkage reagent for SPPS is essentially acid stable. It is useful in combination with Fmoc-amino acids. Its peptide esters are usually cleaved by basic or nucleophilic reagents, especially by ammonia in the preparation of peptide amides.
4-(Hydroxymethyl)benzoic Acid is an intermediate in the synthesis of Eprosartan (CAS: 133040-01-4), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive agent. 

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