Docetaxel CAS 114977-28-5 Assay 98.0%~102.0%
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Docetaxel (Taxotere) (CAS: 114977-28-5) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Docetaxel, Please contact: alvin@ruifuchem.com
| Chemical Name | Docetaxel |
| Synonyms | Taxotere; Taxotere Anhydrous; Docetaxel Anhydrous; N-Debenzoyl-N-tert-Butoxycarbonyl-10-Deacetyltaxol; RP-56976 |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 114977-28-5 |
| Molecular Formula | C43H53NO14 |
| Molecular Weight | 807.89 g/mol |
| Melting Point | 186.0~192.0℃(dec.) |
| Density | 1.38 |
| Solubility | Very Soluble in Acetone, Dimethylformamide. Soluble in Ethanol, Dichloromethane, Methanol. Insoluble in Water |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | White Crystalline Powder | White Crystalline Powder |
| Identification | IR & HPLC | Conforms |
| Specific Rotation [a]20/D | -42.0° to -45.0° (C=1 in EtOH) | -43.1° |
| Loss on Drying | <3.00% | 2.05% |
| Residue on Ignition | <0.10% | 0.04% |
| Heavy Metals (Pb) | ≤20ppm | <20ppm |
| Arsenic (As) | ≤1.5ppm | <1.5ppm |
| Related Substances | ||
| Maximum Single Impurity | <0.50% | <0.50% |
| Total Impurities | <1.00% | <1.00% |
| Microbial Limit Tests | ||
| TAMC | ≤100cfu/g | <100cfu/g |
| TYMC | ≤10cfu/g | <10cfu/g |
| Bacterial Endotoxins | ≤0.3IU/mg | <0.3IU/mg |
| Assay / Analysis Method | 98.0%~102.0% (On the Anhydrous and Solvent-Free Basis) | 100.9% |
| Conclusion | The product has been tested and complies with the given specifications | |
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture. Incompatible with strong oxidizing agents.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Symbols Xi - Irritant
Risk Codes
R36/37/38 - Irritating to eyes, respiratory system and skin.
R61 - May cause harm to the unborn child
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37 - Wear suitable protective clothing and gloves.
S53 - Avoid exposure - obtain special instructions before use.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs 1544
WGK Germany 3
RTECS DA4172750
HS Code 2932999029
Hazard Class 6.1(b)
Packing Group III
Toxicity LD50 intravenous in dog: 2500ug/kg
Docetaxel (Taxotere) (CAS: 114977-28-5) sold as Taxotere or Docecad, is a well-established anti-mitotic chemotherapy medication that works by interfering with cell division. Docetaxel is approved by the FDA for treatment of locally advanced or metastatic breast cancer, head and neck cancer, gastric cancer, hormone-refractory prostate cancer and non small-cell lung cancer. Docetaxel can be used as a single agent or in combination with other chemotherapeutic drugs as indicated depending on specific cancer type and stage. Docetaxel is a member of the taxane drug class, which also includes the chemotherapeutic medication paclitaxel. Although docetaxel remains twice as potent as paclitaxel (due to docetaxel's effect on the centrosome of the mitotic spindle), the two taxanes have been observed to have comparable efficacy. Several recent articles have found "no evidence that regimens containing docetaxel yield greater benefits than those including paclitaxel." While efficacy between the two agents has been observed to be equivalent, paclitaxel may cause fewer side effects. Additionally, it has been noted that docetaxel is prone to cellular drug resistance via a variety of different mechanisms.
1. Docetaxel is a clinically well established anti mitotic chemotherapy medication (that is, it interferes with cell division).
2. Docetaxel is used mainly for the treatment of breast, ovarian, and non-small cell lung cancer.
3. Docetaxel has an FDA approved claim for treatment of patients who have locally advanced, or metastatic breast or non small-cell lung cancer who have undergone anthracycline based chemotherapy and failed to stop cancer progression or relapsed. An European approval doce-taxel for use in hormone-refractory prostate cancer.
4. Docetaxel is considered better than , as a cytotoxic antimicrotubule.
