Side Chain of Docetaxel CAS 196404-55-4 Docetaxel Intermediate Purity >99.0% (Titration)
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Side Chain of Docetaxel (CAS: 196404-55-4) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Side Chain of Docetaxel, Please contact: alvin@ruifuchem.com
| Chemical Name | (4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-Methoxyphenyl)-4-Phenyloxazolidine-5-Carboxylic Acid |
| Synonyms | Side Chain of Docetaxel; (4S,5R)-3-tert-Butoxycarbony-2-(4-anisyl)-4-Phenyl-5-Oxazolidinecarboxylic Acid; (4S,5R)-2-(4-Methoxy-phenyl)-3-N-Boc-4-Phenyl-3,5-Oxazolidine Carboxylic Acid |
| Stock Status | In Stock, Commercial Scale |
| CAS Number | 196404-55-4 |
| Molecular Formula | C22H25NO6 |
| Molecular Weight | 399.44 g/mol |
| Melting Point | 127.0~137.0℃ |
| Density | 1.238 |
| Storage Temp. | Cool & Dry Place (2~8℃) |
| Shipping | Normal |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 2932999029 |
| Items | Inspection Standards | Results |
| Appearance | White or Off-White Crystalline Powder | Complies |
| Melting Point | 127.0~137.0℃ | 133.8~135.4℃ |
| Specific Rotation [α]20/D | +65.0° to +75.0° | +72.4° |
| UV | λ max 227nm | Complies |
| Related Substance (By HPLC) | ≤2.00% | 0.7% |
| Loss on Drying | <0.50% | 0.2% |
| Purity / Analysis Method | >99.0% (By Titration) | 99.4% |
| 1 H NMR Spectrum | Conforms to Structure | Complies |
| Conclusion | The product has been tested & complies with the given specifications | |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in a tightly closed container. Store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
(4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-Methoxyphenyl)-4-Phenyloxazolidine-5-Carboxylic Acid (Side Chain of Docetaxel) (CAS: 196404-55-4) is an intermediate/impurity for Docetaxel (CAS: 114977-28-5) and Docetaxel Trihydrate (CAS: 148408-66-6). It can also be used to synthesize quinoline-docetaxel analogues which exhibit anticancer activity.
Docetaxel is a taxane, antineoplastic, and anticancer drug used to treat locally advanced or metastatic breast cancer, even after the failure of cisplatin therapy. Its anti-tumor efficacy has been proven in in vitro tests to be 1.3-12 times that of paclitaxel. Clinical studies have shown that it is more effective than paclitaxel against anthracycline resistant breast cancer. Docetaxel is currently the most effective for the second-line treatment of anthracycline resistant breast cancer. In single cell therapy and combined chemotherapy for non-small cell lung cancer, it is one of the most effective drugs. It can be used for cancer of the uterus, and to study antibiotics, cell biology, cell signaling, neuroscience, apoptosis, and cell cycles. It is also used to study hair loss caused by docetaxel chemotherapy, and to prevent and treat small-cell lung cancer in patients contraindicated for chemotherapy. It is also used to investigate the roles of hypoxia-inducible factors-1α and 2α in androgen-insensitive prostate cancer cells.
