Cetrorelix Acetate CAS 130143-01-0 GnRH Antagonist Peptide Purity (HPLC) ≥98.0% High Quality

Short Description:

Chemical Name: Cetrorelix Acetate

CAS: 130143-01-0

Appearance: White Powder 

Peptide Purity (HPLC): ≥98.0% 

Synthetic Antagonist of GnRH Receptor 

GMP Peptides, API, High Quality 

Contact: Dr. Alvin Huang    

Mobile/Wechat/WhatsApp: +86-15026746401 

E-Mail: alvin@ruifuchem.com 

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Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Cetrorelix Acetate (CAS: 130143-01-0) with high quality. Cetrorelix Acetate is a gonadotropin-releasing hormone (GnRH) antagonist. Ruifu Chemical supplys a series of GMP peptides. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Cetrorelix Acetate, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name Cetrorelix Acetate
Synonyms  N-Acetyl-3-(2-Naphthalenyl)-D-Alanyl-4-Chloro-D-Phenylalanyl-3-(3-Pyridinyl)-D-Alanyl-L-Seryl-L-Tyrosyl-N5-(Aminocarbonyl)-D-Ornithyl-L-Leucyl-L-Arginyl-L-Prolyl-D-Alaninamide Diacetate; NS-75A Diacetate; SB-075 Diacetate
Sequences Ac-3-(2-naphthyl)-D-Ala-4-Chloro-D-Phe-3(3-pyridyl)-D-Ala-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2
CAS Number 130143-01-0
Stock Status In Stock, Production Scale Up to Kilograms
Molecular Formula C70H92N17O14
Molecular Weight 1551.16
Storage Temp.  Cool & Dry Place (-20℃). Refrigerator 
Shelf Life >2 Years if Stored Properly
Category   GMP Peptides  
Document COA, MS, HPLC, NMR, MSDS, etc. 
Brand Ruifu Chemical


Item Specifications
Appearance White Powder  
Peptide Purity (by HPLC) ≥98.0% (by Area Integration)
Peptide Content ≥80.0% (by %N)
Amino Acid Composition 10% of Theetical
Acetate Content ≤10.0% (by HPLC)
TFA Content ≤1.0%
Single Impurity ≤1.0% (by HPLC)
Water Content (Karl Fischer) ≤8.0%
Assay 95.0~105.0% (By Anhydrous, Acetic Acid-Free)
MS Consistent
Test Standard Enterprise Standard
Shipping Requirements Ice Bags, Desiccant Bags
Origin of Product Synthetic
Attention Only for Research, Not for Human Use
Usage Synthetic Antagonist of GnRH Receptor 

Package & Storage:

Package: Plastic vial (dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery. 






Cetrorelix Acetate (CAS 130143-01-0) is is a gonadotropin-releasing hormone (GnRH) antagonist that is marketed primarily under the brand name Cetrotide. A synthetic decapeptide, it is used is used in assisted reproduction to inhibit premature luteinizing hormone surges. The drug works by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Cetrorelix Acetate is composed of a variety of non-natural amino acids that prevent early ovulation in clinical trials, leading to ovulation collection and assisted reproductive technology therapy for patients undergoing controlled ovarian stimulation.
Indication Cetrorelix Acetate is an artificial hormone that blocks the effects of gonadotropin-releasing hormone (GnRH). In assisted reproductive technology, in patients with controlled ovarian stimulation, prevent premature ovulation.
Pharmacological action Cetrorelix Acetate is a gonadotropin-releasing hormone (GnRH) antagonist. GnRH can bind to membrane receptors of pituitary cells. Cetrorelix acetate competitively binds to these receptors with endogenous GnRH, thereby dose-dependently inhibiting the secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) by the adenohypophysis. The inhibitory effect was produced immediately after the administration of cetrorelix acetate, and the inhibitory effect could be maintained by continuous treatment. for women, Cetrorelix Acetate can delay the LH peak, thereby delaying ovulation. For women undergoing ovarian stimulation, the duration of action was dose-dependent. A single dose of cetrorelix 3mg was estimated to have an inhibitory effect of at least 4 days, with an inhibitory effect of approximately 70% on Day 4. Repeated administration of cetrorelix acetate 0.25mg every 24 hours can maintain its effect. The hormone-antagonizing effect of Cetrorelix Acetate was completely reversed at the end of treatment in both animals and humans.
Biological activity Cetrorelix Acetate is a potent antagonist of the GnRH receptor with an IC50 value of 1.21 nM.
Target IC50: 1.21 nM GnRH.  

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