Benzyl Chloroformate (Cbz-Cl) CAS 501-53-1 Purity >97.0% (GC) Factory

Benzyl Chloroformate (Cbz Chloride; Cbz-Cl) (CAS: 501-53-1) is an organic compound that belongs to the family of chloroformates.
Benzyl Chloroformate was first prepared by Leonidas Zervas in the early 1930s who used it for the introduction of the benzyloxycarbonyl protecting group, which became the basis of the Bergmann-Zervas carboxybenzyl method of peptide synthesis he developed with Max Bergmann. This was the first successful method of controlled peptide chemical synthesis and for twenty years it was the dominant procedure used worldwide until the 1950s. To this day, benzyl chloroformate is often used for amine group protection.
Benzyl chloroformate is widely used as a reagent in organic synthesis, especially in the preparation of carboxylic acid derivatives and peptides. It is also used for the protection of amino groups in organic compounds.
Benzyl Chloroformate is used as a reagent in peptide synthesis to protect the amine functionality as the benzyloxycarbonyl (Cbz or Z) derivative. Cbz-protected anilines were prepared directly from aromatic carboxylic acids, sodium azide and Cbz-Cl. Protecting reagent in peptide synthesis.
Benzyl Chloroformate is used as an amino protectant in the synthesis of antibiotics and also as an intermediate in pesticides. Benzyl Chloroformate is widely used as a reactive chemical intermediate in pesticides, pharmaceutical, agricultural and organic chemicals. It is useful for the introduction of carboxybenzyl (cbz) protecting group for amines such as aniline in organic synthesis.