Fmoc-Cl CAS 28920-43-6 9-Fluorenylmethyl Chloroformate Purity >99.0% (HPLC) Factory Protecting Reagent

9-Fluorenylmethyl Chloroformate (Fmoc-Cl; Fmoc Chloride) (CAS: 28920-43-6) is mainly used for solid-phase polypeptide synthesis, can be used as N-protecting reagent for oligonucleotide and peptide syntheses. Fmoc-Cl can act as reagent for the introduction of Fmoc-amino-protecting group, which is stable towards acids but is readily cleaved under mildly basic non-hydrolytic conditions.
Used for organic synthesis (amino acid protecting group). Amino acid derivative reagent, fluorescence detection, can effectively detect the reaction products by HPLC, but will produce dipeptide and tripeptide impurities, and the reagent is not easy to preserve.
Fmoc-Cl is used to prepare N-Fmoc amino acids in solid-phase polypeptide synthesis. Amino protective reagents for the synthesis of bicyclic proline analogs; Amino acid derivative reagents, which can be used for HPLC and capillary electrophoresis analysis, N-protection in polypeptides and oligonucleotide synthesis
Fmoc-Cl is a protective reagent for primary and secondary amines and is sensitive to bases. It is usually used for the synthesis of polypeptides or derivatization before amino and amino acid HPLC analysis and fluorescence detection.
Safety: A poison. Mutation data reported. A corrosive. When heated to decomposition it emits toxic vapors of Cl-.
Long-term storage at room temperature will slowly decompose. Easy to absorb moisture and decompose in water.
Soluble in organic solvents such as CH2Cl2, THF and dioxane. It can react with alcohol, ammonia or amine, or water.