2-(1H-1,2,4-Triazol-1-yl)-2′,4′-Difluoroacetophenone CAS 86404-63-9 Voriconazole Intermediate Purity >98.0% (HPLC)

Short Description:

Name: 2-(1H-1,2,4-Triazol-1-yl)-2′,4′-Difluoroacetophenone

Synonyms: 2,4-Difluoro-α-(1H-1,2,4-Triazolyl)acetophenone 

CAS: 86404-63-9

Purity: >98.0% (HPLC)

Appearance: Light Yellow to Off-White Crystalline Powder

Intermediate of Voriconazole (CAS: 137234-62-9) 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Voriconazole Intermediates:

86404-63-9 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 2-(1H-1,2,4-Triazol-1-yl)-2',4'-Difluoroacetophenone (CAS: 86404-63-9) with high quality, intermediate of Voriconazole (CAS: 137234-62-9). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Voriconazole Intermediates, Please contact: alvin@ruifuchem.com

86404-63-9 - Chemical Properties:

Chemical Name 2-(1H-1,2,4-Triazol-1-yl)-2',4'-Difluoroacetophenone  
Synonyms 2,4-Difluoro-α-(1H-1,2,4-Triazolyl)acetophenone; 2,4-Difluoro-alpha-(1H-1,2,4-Triazolyl)acetophenone; 1-(2,4-Difluorobenzoylmethyl)-1H-1,2,4-Triazole; 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-Triazol-1-yl)ethanone; 2',4'-Difluoro-2-(1H-1,2,4-Triazol-1-yl)acetophenone; 2',4'-Difluoro-alpha-(1H-1,2,4-Triazol-1-yl)acetophenone
Impurity   USP Voriconazole Related Compound C; Voriconazole EP Impurity A
Stock Status In Stock, Commercial Production
CAS Number 86404-63-9
Molecular Formula C10H7F2N3O
Molecular Weight 223.18 g/mol
Melting Point 103.0~108.0℃(lit.) 
Boiling Point 388.0±52.0℃
Density 1.39±0.10 g/cm3 
COA & MSDS Available
Place of Origin  Shanghai, China
Brand Ruifu Chemical

86404-63-9 - Specifications:

Items Specifications  Results
Appearance Light Yellow to Off-White Crystalline Powder Light Yellow Crystalline Powder
Melting Point 103.0~108.0℃ 104.3℃
Water by Karl Fischer  <0.50% 0.2%
Purity / Analysis Method >98.0% (HPLC)  99.2%
Infrared Spectrum Conforms to Structure Conforms 
1H NMR Spectrum Conforms to Structure Conforms 
Conclusion The product has been tested and complies with the given specifications
Application Intermediate of Voriconazole (CAS: 137234-62-9)

Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

86404-63-9 - Risk and Safety:

Hazard Symbols Xi - Irritant
Xn - Harmful
Risk Codes R36/37/38 - Irritating to eyes, respiratory system and skin.
R22 - Harmful if swallowed
Safety Description 24/25 - Avoid contact with skin and eyes.
WGK Germany 3
HS Code 2933990099

86404-63-9 - Application:

2-(1H-1,2,4-Triazol-1-yl)-2',4'-Difluoroacetophenone (CAS: 86404-63-9), a pharmaceutical and chemical intermediate, is used as an intermediate of Voriconazole (CAS: 137234-62-9).
Voriconazole is a broad-spectrum triazole antifungal ,it is primarily used for the treatment of progressive, possibly life-threatening infections in immune deficiency patients. Indications include: immunosuppressed patients with severe fungal infections, acute invasive aspergillosis (the most common pathogen is Aspergillus fumigatus, followed by A. flavus, Aspergillus niger and Aspergillus soil), severe invasive infections caused by fluconazole-resistant Candida (including C. krusei) severe infection caused by Foot actinomycetes bacteria genus and Fusarium bacteria genus.   

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