4-Methylumbelliferone (4-MU) CAS 90-33-5 Purity >98.0% (HPLC) Factory
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 4-Methylumbelliferone (4-MU; 7-Hydroxy-4-Methylcoumarin) (CAS: 90-33-5) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase 4-Methylumbelliferone, Please contact: alvin@ruifuchem.com
| Chemical Name | 4-Methylumbelliferone |
| Synonyms | 4-MU; Hymecromone; 7-Hydroxy-4-Methylcoumarin; 7-Hydroxy-4-Methyl-Coumarin; β-Methylumbelliferone; beta-Methylumbelliferone; 7-Hydroxy-4-Methyl-2H-1-Benzopyran-2-one; 4-Methyl-7-Hydroxycoumarin; Coumarin 4 |
| Stock Status | In Stock, Production Capacity to Tons per Month |
| CAS Number | 90-33-5 |
| Molecular Formula | C10H8O3 |
| Molecular Weight | 176.17 g/mol |
| Melting Point | 187.0~191.0℃ |
| Water Solubility | Practically Insoluble in Water |
| Solubility | Soluble in Ethanol. Slightly Soluble in Ether, Chloroform |
| Storage Temp. | Cool & Dry Place |
| COA & MSDS | Available |
| Shelf Life | 60 Months |
| Brand | Ruifu Chemical |
| Items | Inspection Standards | Results |
| Appearance | Off-White to Yellow Crystalline Powder | Complies |
| Melting Point | 187.0~191.0℃ | 189.4~190.6℃ |
| Water by Karl Fischer | <0.50% | 0.45% |
| Residue on Ignition | <0.20% | 0.06% |
| Heavy Metals (Pb) | ≤10ppm | <10ppm |
| Iron (Fe) | ≤10ppm | <10ppm |
| Arsenic (As2O3) | ≤1ppm | <1ppm |
| Purity / Analysis Method | >99.0% (HPLC) | 99.7% |
| Infrared Spectrum | Conforms to Structure | Complies |
| Proton NMR Spectrum | Conforms to Structure | Complies |
| Conclusion | The product has been tested & complies with the given specifications | |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Risk Codes
R36/37/38 - Irritating to eyes, respiratory system and skin.
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection
S36 - Wear suitable protective clothing.
WGK Germany 2
RTECS GN7000000
TSCA Yes
HS Code 2932209090
Hazard Note Irritant
Toxicity LD50 oral in rat: 3850mg/kg
4-Methylumbelliferone (4-MU; 7-Hydroxy-4-Methylcoumarin) (CAS: 90-33-5) , a hydroxycoumarin that is umbelliferone substituted by a methyl group at position 4.
4-Methylumbelliferone is a dietary supplement that inhibits hyaluronic acid (HA) synthesis. Hyaluronan (HA) is a prominent component of the extracellular matrix at many sites of chronic inflammation, including type 1 diabetes (T1D), multiple sclerosis, and numerous malignancies. 4-MU is an already approved drug in Europe and Asia called “hymecromone” where it is used to treat biliary spasm.
Choloretic, spasmolytic, sunscreen, analytical reagent.
Pharmaceutical Applications: 4-Methylumbelliferone is primarily used in synthesizing medicinal compounds and as a building block for fluorescent probes. Applications include synthesis of: coumarin triazole derivatives as potential antimicrobial agents. coumarin salen-based fluorescence sensors for Mg2+ detection. pyranocoumarin derivatives as anti-hyperglycemic and anti-dyslipidemic agents. coumarin piperazine derivatives as potential multireceptor atypical antipsychotics. 4-methylumbelliferyl T-antigen as a substrate for endo-α-N-acetylgalactosaminidase.
Biological Activity 4-methylumbelliferone is a hyaluronic acid (ha) synthesis inhibitor. the activation of has2 and the over-production of ha are existed in many metastatic tumor cell lines. increased synthesis of ha is often associated with increased metastatic potential and invasivity in tumor cells.
