4-Chloro-7-Tosyl-7H-Pyrrolo[2,3-d]pyrimidine CAS 479633-63-1 Purity >98.0% (HPLC) Tofacitinib Citrate Intermediate

Short Description:

4-Chloro-7-Tosyl-7H-Pyrrolo[2,3-d]pyrimidine 

CAS: 479633-63-1

Purity: >98.0% (HPLC)

Appearance: White to Light Yellow Powder 

Intermediate of Tofacitinib Citrate (CAS: 540737-29-9)

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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479633-63-1 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 4-Chloro-7-Tosyl-7H-Pyrrolo[2,3-d]pyrimidine (CAS: 479633-63-1) with high quality, intermediate of Tofacitinib Citrate (CAS: 540737-29-9). Ruifu Chemical has been supplying pharmaceutical intermediates and APIs, fine chemicals more than 15 years. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase Tofacitinib Citrate Intermediates or other products, please contact us by e-mail: alvin@ruifuchem.com

Intermediates of Tofacitinib Citrate:

479633-63-1 - Chemical Properties:

Chemical Name 4-Chloro-7-Tosyl-7H-Pyrrolo[2,3-d]pyrimidine
Synonyms 4-Chloro-7-Tosyl-7H-Pyrrolo[2,3-δ]pyrimidine; 4-Chloro-7-(p-Toluenesulfonyl)-7H-Pyrrolo[2,3-d]pyrimidine; 4-Chloro-7-(p-Toluenesulfonyl)-7H-Pyrrolo[2,3-δ]pyrimidine; 4-Chloro-7-[(4-Methylbenzene)sulfonyl]-7H-Pyrrolo[2,3-d]pyrimidine; Tofacitinib Impurity R
Stock Status In Stock, Commercial Production  
CAS Number 479633-63-1
Molecular Formula C13H10ClN3O2S 
Molecular Weight 307.75 g/mol
Melting Point 145.0 to 155.0℃ 
Density 1.49 g/cm3 
Storage Temperature Store Long-Term at 2-8℃
Shipping Conditions Ambient
COA & MSDS Available
Origin of Product    Shanghai, China
Product Categories
Pharmaceutical Intermediates
Brand Ruifu Chemical

479633-63-1 - Specifications:

Items Specifications  Results
Appearance White to Light Yellow Powder    Off-White Powder   
1H NMR Spectrum Conforms to Structure   Conforms
Purity / Analysis Method >98.0% (HPLC Area)  99.9%
Identified Impurity 1   ≤0.20% (HPLC Area)  0.004%
Identified Impurity 2 ≤0.15% (HPLC Area)  0.009%
Identified Impurity 3  ≤1.50% (HPLC Area)  0.10%
Total Impurities ≤2.00% (HPLC Area)  0.14%
Any Unspecified Impurity ≤0.20% (HPLC Area)  0.03%
Melting Point 145.0~155.0℃ 150.0~151.0℃
Loss on Drying <2.00% 0.22%
Water by Karl Fischer  <1.00% 0.09%
Residue on Ignition <0.50% 0.16%
Ni Metal Residue <60ppm (Calculated on Dried Basis) 0.05ppm 
Conclusion The product has been tested and complies with the given specifications
Application Intermediate of Tofacitinib Citrate (CAS: 540737-29-9)

479633-63-1 - Package/Storage/Shipping:

Package: Fluorinated bottle, Aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃), well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

479633-63-1 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

479633-63-1 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

479633-63-1 - Risk and Safety:

Hazard Symbols Xn - Harmful 
Risk Codes 22 - Harmful if swallowed                          
Hazard Class IRRITANT
HS Code  2933599099

479633-63-1 - Application:

4-Chloro-7-Tosyl-7H-Pyrrolo[2,3-d]pyrimidine (CAS: 479633-63-1), is an important intermediate in the synthesis of Tofacitinib Citrate (CAS: 540737-29-9).
Tofacitinib Citrate, is a king of drugs developed by the US pharmaceutical company Pfizer for treating rheumatoid arthritis, trade name Xeljanz, for the treatment of methotrexate inadequate response or intolerance to severe active rheumatoid arthritis (RA) in adult patients. This product is a Janus kinase inhibitor, administered twice daily.
November 6, 2012, the US Food and Drug Administration (FDA) and Pfizer jointly announced Tofacitinib Citrate is approved for the treatment of methotrexate inadequate response or intolerance to severe active rheumatoid joints arthritis (RA) in adult patients.  

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