Hoveyda-Grubbs Catalyst 2nd Generation CAS 301224-40-8 Purity >98.0% (NMR)
Ruifu Chemical is the leading manufacturer of Hoveyda-Grubbs Catalyst 2nd Generation (CAS: 301224-40-8) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Hoveyda-Grubbs Catalyst 2nd Generation, Please contact: alvin@ruifuchem.com
| Chemical Name | Hoveyda-Grubbs Catalyst 2nd Generation |
| Synonyms | Umicore Hoveyda-Grubbs Catalyst M720; Hoveyda-Grubbs Catalyst; Hoveyda-Grubbs 2nd; Hoveyda-Grubbs Catalyst® M72 (C627); Hoveyda-Grubbs Second Generation Catalyst; Second Generation Hoveyda Grubbs Catalyst; Second-Generation Hoveyda Catalyst; Grubbs-Hoveyda Catalyst; Hoveyda II Catalyst; Hoveyda Catalyst; (1,3-Bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(o-isopropoxyphenylmethylene)ruthenium; Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene](2-isopropoxyphenylmethylene)ruthenium(II); [1,3-Bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene]-dichloro-{[2-(1-methylethoxy)-phenyl]-methylene}-ruthenium |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 301224-40-8 |
| Molecular Formula | C31H37Cl2N2ORu |
| Molecular Weight | 625.62 g/mol |
| Melting Point | 216.0~220.0℃(lit.) |
| Store Under Inert Gas | Store Under Inert Gas |
| Sensitive | Hygroscopic. Air Sensitive, Light Sensitive |
| COA & MSDS | Available |
| Place of Origin | Shanghai, China |
| Product Categories |
Catalysts |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | Green Solid | Green Solid |
| Purity / Analysis Method | >98.0% (NMR) | 98.25% |
| Conclusion | The product has been tested and complies with the given specifications | |
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light, stored under nitrogen. Avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
| WGK Germany | 3 |
Hoveyda-Grubbs Catalyst 2nd Generation (CAS: 301224-40-8) is a phosphine free version of Grubbs 2nd Generation Catalyst with comparable reactivity, but initiates more readily at lower temperatures. Efficient for metathesis of electron-deficient substrates including fluorinated olefins. Demonstrated in multiple large-scale pharmaceutical applications.
Hoveyda-Grubbs Catalyst 2nd Generation can be used as a catalyst for olefin cross-metathesis with fluorinated olefins (CM), ring-closing metathesis (RCM), ring-opening metathesis (ROM), and a sequence of a metathesis reaction and subsequent dihydroxylation of the newly formed double bond.
In the first generation Hoveyda-Grubbs Catalyst, one of the phosphine ligands is replaced by an isopropyloxy group attached to the benzene ring. Its second generation has the other phosphine ligand replaced by NHC.
Grubbs catalyst has poor thermal stability and is prone to decomposition at higher temperatures. Amir H. Hoveyda et al. introduced large nucleophilic isopropoxychelate ligands into the molecule, which improved the thermal stability of the catalysts, which were called "Hoveyda-Grubbs catalysts". It is also divided into the first generation and the second generation, respectively, derived from the corresponding Grubbs catalyst, but one of the tricyclohexylphosphine groups in the original Grubbs catalyst is replaced by the isopropoxy group of the benzene ring. The disadvantage of these catalysts is that the catalytic activity is general, and it is difficult to separate the catalyst from the reaction system after the reaction.
The first generation Hoveyda-Grubbs catalyst is suitable for the loop closure complex decomposition of terminal olefin. The second generation Hoveyda-Grubbs catalyst is suitable for the ring closing, ring opening and cross decomposition reactions of electron-deficient alkenes.
Although the first and second generation Grubbs catalysts have high catalytic activity, some reactions still require a large amount, sometimes even 50mol% of the catalyst, and the catalyst can not be reused. In addition, the metal residues in the reaction products are difficult to remove in the post-treatment. Hoveyda catalysts are stable in air and water and can be prepared by chromatographic column separation.
