Hoveyda-Grubbs Catalyst 1st Generation CAS 203714-71-0 Purity >97.0% (GC)

Hoveyda-Grubbs Catalyst 1st Generation (CAS: 203714-71-0) is a ruthenium-based olefin metathesis catalyst.
Proven to be useful in Ring-Closing Metathesis (RCM) to form macrocycles. Also employed in a pivotal, macrocyclic ring-closing metathesis in the multi-step synthesis of an HCV protease inhibitor.
Grubbs catalysts has poor thermal stability and is prone to decomposition at higher temperatures. Professor Amir H. Hoveyda and his co-workers introduced large nucleophilic isopropoxychelate ligands into the molecule, which improved the thermal stability of the catalysts, which were called "Hoveyda-Grubbs catalysts". It is also divided into the first generation and the second generation, respectively, derived from the corresponding Grubbs catalyst, but one of the tricyclohexylphosphine groups in the original Grubbs catalyst is replaced by the isopropoxy group of the benzene ring.
The Hoveyda-Grubbs Catalyst 1st Generation is a ruthenium-based catalyst that has been widely used in organic synthesis for the past two decades. It is a highly efficient and versatile catalyst that has been used for a variety of reactions, including olefin metathesis, hydroformylation, and cross-coupling. The catalyst is also used in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients. Also used in the synthesis of complex organic molecules, polymers, natural products, etc.
Recent studies have focused on exploring the potential applications of the Hoveyda-Grubbs Catalyst 1st Generation in fields such as materials science, drug discovery, and green chemistry. Researchers have also been investigating ways to improve the catalyst's performance and efficiency.
Despite its many benefits, the Hoveyda-Grubbs Catalyst 1st Generation does have limitations. For example, it can be sensitive to air and moisture, which can impact its performance. Furthermore, the catalyst's activity can decline over time, making it less effective.
Future directions for the catalyst include the development of more efficient and selective catalysts, the development of catalysts with longer shelf lives, and the development of catalysts that are more cost-effective.