3-Ethynylaniline CAS 54060-30-9 Purity >99.0% (GC) Erlotinib Hydrochloride Intermediate

Short Description:

Chemical Name: 3-Ethynylaniline

Synonyms: 3-Aminophenylacetylene

CAS: 54060-30-9

Purity: >99.0% (GC)

Appearance: Light Yellow to Brown Liquid

Intermediate of Erlotinib Hydrochloride (CAS: 183319-69-9)

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Product Detail

Product Tags

Description:

Leading manufacturer and supplier of Erlotinib Hydrochloride Intermediates

Erlotinib Hydrochloride	CAS 183319-69-9
3-Ethynylaniline	CAS 54060-30-9
6,7-Bis(2-Methoxyethoxy)-4(3H)-Quinazolinone	CAS 179688-29-0

Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	3-Ethynylaniline
Synonyms	m-Ethynylaniline; 3-Aminophenylacetylene; m-Aminophenylacetylene; 3-Ethynylbenzeneamine; 3-Ethynyl-Phenylamine
CAS Number	54060-30-9
Stock Status	In Stock, Production Capacity 50MT/Month
Molecular Formula	C8H7N
Molecular Weight	117.15
Sensitive	Air Sensitive, Light Sensitive
Boiling Point	120℃/20 mmHg
Water Solubility	Insoluble in Water
Brand	Ruifu Chemical

Specifications:

Item	Specifications	Results
Appearance	Light Yellow to Brown Liquid	Complies
Purity / Analysis Method	>99.0% (GC)	99.85% (GC)
Water by Karl Fischer	<0.50%	0.02%
Residue on Ignition	<0.20%	0.01%
Total Impurities	<1.00%	0.15%
Specific Gravity (20/20℃)	1.041~1.048	Complies
Refractive Index n20/D	1.614~1.6195	Complies
Infrared Spectrum	Conforms to Structure	Complies
Proton NMR Spectrum	Conforms to Structure	Complies
Test Standard	Enterprise Standard	Complies
Usage	Pharmaceutical Intermediate; Erlotinib Hydrochloride Intermediate

Package & Storage:

Package: Fluorinated Bottle, 25kg/Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

FAQ:

54060-30-9 - Risk and Safety:

Risk Codes
36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S37/39 - Wear suitable gloves and eye/face protection
S36/37 - Wear suitable protective clothing and gloves.
UN IDs UN 1993 3/PG 3
WGK Germany 3
TSCA Yes
HS Code 2921499090
Hazard Class 3
Packing Group Ⅲ

54060-30-9 - Application:

3-Ethynylaniline, also known as 3-Aminophenylacetylene (CAS: 54060-30-9) is used as a pharmaceutical intermediate. 3-Ethynylaniline is an intermediate of Erlotinib Hydrochloride (CAS: 183319-69-9). Erlotinib Hydrochloride is a small molecule tyrosine kinase inhibitor which acts reversibly on epidermal growth receptors, a hydrochloride of erlotinib, a molecular-targeted drug. The US Food and Drug Administration (FDA) has approved erlotinib (Tarceva) combined with gemcitabine as a first-line treatment for locally advanced and metastatic pancreatic cancer. It is mainly used as a second- or third-line treatment for locally advanced or metstatic non-small cell lung cancer (NSCLC) and as a treatment for pancreatic cancer. It is used as a tyrosine inhibitor for NSCLC treatment. Erlotinib Hydrochloride, a quinazoline derived small molecule inhibitor of epidermal growth receptor (EDGFR) tyrosine kinase, was approved in November, 2004, for the treatment of advanced or metastatic non-smallcell lung cancer.