2-Chloro-5-Iodobenzoic Acid CAS 19094-56-5 Empagliflozin Intermediate Assay ≥99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 2-Chloro-5-Iodobenzoic Acid (CAS: 19094-56-5) with high quality, intermediates of Empagliflozin (CAS: 864070-44-0). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase 2-Chloro-5-Iodobenzoic Acid, Please contact: alvin@ruifuchem.com
| Chemical Name | 2-Chloro-5-Iodobenzoic Acid |
| CAS Number | 19094-56-5 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C7H4ClIO2 |
| Molecular Weight | 282.46 |
| Density | 2.077±0.06 g/cm3 |
| Melting Point | 161.0~163.0℃(lit.) |
| Solubility | Soluble in Methanol |
| Sensitive | Light Sensitive |
| COA & MSDS | Available |
| Place of Origin | Shanghai, China |
| Product Categories | Intermediates of Empagliflozin (CAS: 864070-44-0) |
| Brand | Ruifu Chemical |
| Item | Specifications | Specifications |
| Appearance | White or Pale Yellow Crystals | White Crystals |
| Assay / Analysis Method | ≥99.0% (HPLC) | 99.91% (HPLC) |
| Melting Point | 161.0~163.0℃ | 161.7~162.5℃ |
| Loss on Drying | ≤0.50% | 0.15% |
| Residue on Ignition | ≤0.20% | 0.06% |
| Total Impurities | ≤1.00% | 0.09% |
| Heavy Metals | ≤20ppm | <20ppm |
| Residual Solvent | Ethanol | Conforms |
| Infrared Spectrum | Conforms to Structure | Conforms |
| Test Standard | Enterprise Standard | Conforms |
| Usage | Intermediate of Empagliflozin (CAS: 864070-44-0) | |
2-Chloro-5-Iodobenzoic Acid (CAS 19094-56-5) Synthetic Route
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.
Risk Codes
R25 - Toxic if swallowed
R41 - Risk of serious damage to eyes
R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39 - Wear eye / face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S60 - This material and its container must be disposed of as hazardous waste.
S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs UN 2811 6.1/PG 3
WGK Germany 3
HS Code 2916399090
Hazard Note Irritant
Packing Group III
2-Chloro-5-Iodobenzoic Acid (CAS: 19094-56-5) can be used as a pharmaceutical intermediate in the synthesis of Empagliflozin (CAS: 864070-44-0). Empagliflozin (trade name Jardiance) is an inhibitor of the sodium glucose co-transporter-2 (SGLT-2), and causes sugar in the blood to be excreted by the kidneys and eliminated in urine. On August 1, 2014, the Food and Drug Administration (FDA) officially approved the drug for the treatment of type 2 diabetes, to improve and control blood glucose of adults. Empagliflozin is the third SGLT-2 inhibiting drugs approved by FDA. Another two SGLT-2 inhibitor drugs, Canagliflozin and Dapagliflozin, belonging to Johnson Pharmaceuticals, AstraZeneca and Bristol-Myers Squibb respectively, are approved by FDA in November 2013 and January 2014 respectively.
