Vismodegib (GDC-0449) CAS 879085-55-9 Assay ≥99.0% (HPLC)

Short Description:

Chemical Name: Vismodegib

Synonyms: GDC-0449 

CAS: 879085-55-9

Assay: ≥99.0% (HPLC)

Appearance: White to Off-White Powder 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401


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879085-55-9 - Description:

Shanghai Ruifu Chemical is the leading supplier of Vismodegib (GDC-0449) (CAS: 879085-55-9) with high quality.
Ruifu Chemical has been supplying APIs (Active Pharmaceutical Ingredients) and pharmaceutical intermediates more than 15 years. 
Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase Vismodegib (GDC-0449), please contact us by e-mail:

879085-55-9 - Chemical Properties:

Chemical Name Vismodegib
Form Free Base
Synonyms GDC-0449; 2-Chloro-N-[4-Chloro-3-(2-Pyridinyl)phenyl]-4-(Methylsulfonyl)benzamide
CAS Number 879085-55-9
Molecular Formula C19H14Cl2N2O3S
Molecular Weight 421.30 g/mol
Melting Point 179.0-181.0℃ 
Density 1.440 g/cm3
Storage Temperature Store Long-Term at 2-8℃
Shipping Temperature Shipped Ambient
COA & MSDS Available
Origin of Product    Shanghai, China
Shelf Life  2 Years If Sealed and Stored Properly
Product Categories
API (Active Pharmaceutical Ingredient) 
Caution Not For Use in Humans, Diagnostics or Therapeutics. Research Use Only.
Brand Ruifu Chemical

879085-55-9 - Specifications:

Items Specifications  Results
Appearance White to Off-White Powder  Conforms  
Water by Karl Fischer  ≤0.50% 0.20%
Vismodegib Assay                ≥99.0% (HPLC)  99.6%
Infrared Spectrum Conforms to Structure   Conforms 
NMR Spectrum Conforms to Structure   Conforms   
Conclusion The product has been tested and complies with the given specifications

879085-55-9 - Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry (2-8℃) and well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

879085-55-9 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

879085-55-9 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: or 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

879085-55-9 - Risk and Safety:

HS Code  2933 3990.99                                

879085-55-9 - Overview:

Vismodegib (GDC-0449) (CAS: 879085-55-9) is one of the first anti-tumor drugs approved by the US Food and Drug Administration (FDA) for the treatment of advanced basal cell carcinoma (BCC) by Genentech Co., Ltd. on January 30, 2012. Since October 2012, Vismodegib (Erivedge) has been approved by the European Union, Switzerland, Australia, Israel, South Korea, Mexico and Ecuador.

879085-55-9 - Use:

Vismodegib (GDC-0449) (CAS: 879085-55-9) is used for the treatment of locally progressive or metastatic basal cell carcinoma in adults who have relapsed after surgery or are not amenable to surgery or radiotherapy; basal cell carcinoma (BCC) is one of the most common forms of skin cancer. It originates from the surface of the skin and does not cause pain. For regular exposure to sunlight or ultraviolet radiation skin disease is the most likely. The R & D and marketing of Vismodegib has brought good news to BCC Patients. Its clinical role is important and the target market is huge, and Vismodegib will grow into a "Giant Bomb" class (> $1 billion) drug in the future.  

879085-55-9 - Mechanism of Action:

Vismodegib (GDC-0449) (CAS: 879085-55-9) has a novel mechanism of action and is a selective Hedgehog signaling pathway inhibitor. Although Hedgehog signaling pathway is active in early life and plays an important role in regulating human growth and development, it is not active in adults. The vast majority of patients with basal cell carcinoma (>90%) have an overactive Hedgehog signaling pathway, which is considered to be the basic molecular driver of basal cell carcinoma. It acts as a competitive Cyclopamine antagonist and acts on the transmembrane G protein-coupled receptor protein (Smoothened) in the Hedgehog signaling pathway. It can block the expression of tumor-regulated genes related to Hedgehog signaling pathway by inhibiting SMO receptors to keep transcription factors GLT-1 and GLT-2 in a non-activated state.

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