Scopolamine Hydrobromide Trihydrate CAS 6533-68-2 Assay 98.5%-102.0%

Short Description:

Name: Scopolamine Hydrobromide Trihydrate 

CAS: 6533-68-2

CAS Anhydrous: 114-49-8

Assay: 98.5%-102.0% (Anhydrous Basis)

Appearance: White to Off-White Crystalline Powder 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401


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6533-68-2 - Description:

Shanghai Ruifu Chemical is the leading manufacturer of Scopolamine Hydrobromide Trihydrate (CAS: 6533-68-2) with high quality. It is primarily used to treat motion sickness and nausea.
Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase Scopolamine Hydrobromide Trihydrate, please contact us by e-mail:

6533-68-2 - Chemical Properties:

Chemical Name Scopolamine Hydrobromide Trihydrate
Synonyms (-)-Scopolamine Hydrobromide Trihydrate; Scopolamine HBr Trihydrate; Hyoscine Hydrobromide Trihydrate; Hyoscine HBr Trihydrate; Scopine Tropate
Stock Status In Stock 
CAS Number 6533-68-2
CAS Anhydrous 114-49-8
Molecular Formula C17H21NO4·HBr·3H2O
Molecular Weight 438.32 g/mol
Melting Point 195.0-199.0℃ (Dry Matter) 
Sensitive Light Sensitive 
Solubility in Water  Almost Transparency 
Storage Temperature Store Long-Term at 2-8℃
Shipping Conditions Ambient
COA & MSDS Available
Origin of Product    Shanghai, China
Caution Not For Human or Veterinary Use. For Research Use Only.
Brand Ruifu Chemical

6533-68-2 - Specifications:

Items Specifications  Results
Appearance White to Off-White Crystalline Powder  Conforms 
Specific Rotation [α]20/D -24.0° - -26.0° (C=5 in H2O) -25.02°
Loss on Drying ≤13.0% 11.27%
Residue on Ignition ≤0.10% 0.01%
Heavy Metals (Pb) ≤10ppm <10ppm 
pH (5% Solution) 4.0-5.5 4.46
Assay / Analysis Method 98.5%-102.0% (Calculated on the Anhydrous Basis) 99.62%
Infrared Spectrum Conforms to Structure   Conforms 
Conclusion The product has been tested and complies with the given specifications

6533-68-2 - Package/Storage/Shipping:

Scopolamine Hydrobromide
C17H21NO4·HBr·3H2O 438.31
hydrobromide trihydrate [6533-68-2]
Anhydrous 384.27 [114-49-8].
» Scopolamine Hydrobromide contains not less than 98.5 percent and not more than 102.0 percent of C17H21NO4·HBr, calculated on the anhydrous basis.
Caution-Handle Scopolamine Hydrobromide with exceptional care, since it is highly potent.
Packaging and storage-Preserve in tight, light-resistant containers.
USP Reference standards <11>-
USP Scopolamine Hydrobromide RS
A: Infrared Absorption <197K>-
Test specimen-Dissolve 3 mg in 1 mL of alcohol, and evaporate the solution on a steam bath to dryness. Dissolve the residue in 0.5 mL of chloroform, add 200 mg of potassium bromide, previously dried at 105° for 30 minutes, and stir frequently for 5 minutes. Allow the chloroform to evaporate to dryness, and stir frequently to obtain a flowing powder residue. Dry the residue on a steam bath for 5 minutes, then immediately compress the residue to a disk.
B: To 1 mL of a solution (1 in 20) add a few drops of chlorine TS, and shake the mixture with 1 mL of chloroform: the latter assumes a brownish color.
Specific rotation <781S>: between -24° and -26°.
Test solution: an amount equivalent to 50 mg of anhydrous Scopolamine Hydrobromide per mL, in water
pH <791>: between 4.0 and 5.5, in a solution (1 in 20).
Water, Method III <921>-Dry it in two stages (see Loss on drying <731>); first at 80° for 2 hours, and then at 105° for an additional 3 hours: it loses not more than 13.0% of its weight.
Residue on ignition <281>: negligible, from 100 mg.
Limit of apoatropine-To 15 mL of a solution (1 in 100) add 0.05 mL of 0.1 N potassium permanganate VS: the solution is not completely decolorized within 5 minutes.
Other foreign alkaloids-To 1 mL of a solution (1 in 20) add a few drops of 6 N ammonium hydroxide: no turbidity is produced. Add 1 N potassium hydroxide to another 1-mL portion of the solution: only a transient whitish turbidity is produced.
Assay-Dissolve about 750 mg of Scopolamine Hydrobromide, accurately weighed, in a mixture of 30 mL of glacial acetic acid and 10 mL of mercuric acetate TS, warming slightly to effect solution. Cool the solution to room temperature, add 2 drops of crystal violet TS, and titrate with 0.1 N perchloric acid VS. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 38.43mg of C17H21NO4·HBr. 

6533-68-2 - Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry (2-8℃) and well-ventilated warehouse away from incompatible substances. Store away from oxidizing agents. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

6533-68-2 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

6533-68-2 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: or 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

6533-68-2 - Risk and Safety:

Hazard Symbols T+ - Very toxic
Risk Codes 26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed.
Safety Description
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S25 - Avoid contact with eyes.
S1 - Keep locked up.
UN IDs UN1544 6.1/PG 3
WGK Germany 1
RTECS YM4550000
HS Code 2934999099
Hazard Class 6.1
Packing Group III

6533-68-2 - Application:

Scopolamine Hydrobromide Trihydrate (CAS: 6533-68-2) is a belladonna alkaloid with anticholinergic properties that is prescribed to treat motion sickness-related nausea and vomiting as well as postoperative nausea and vomiting (PONV). Scopolamine Hydrobromide Trihydrate is a tropane alkaloid discovered in plants belonging to the Solanaceae family that shares structural similarities with the neurotransmitters atropine and hyoscyamine.
Scopolamine Hydrobromide Trihydrate works by blocking certain nerve impulses in the brain, which helps to reduce symptoms of motion sickness and other related conditions.

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