Rabeprazole Chloride Compound CAS 153259-31-5 Assay >99.0% (HPLC) Factory

Short Description:

Chemical Name: 2-Chloromethyl-3-Methyl-4-(3-Methoxypropoxy)pyridine Hydrochloride

Synonyms: Rabeprazole Chloride Compound

CAS: 153259-31-5

Assay: >99.0% (HPLC)

Appearance: Yellowish to Off-White Crystalline Powder

Intermediate of Rebeprazole Sodium CAS 117976-90-6

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153259-31-5 - Description:

Shanghai Ruifu Chemical is the leading manufacturer of 2-Chloromethyl-3-Methyl-4-(3-Methoxypropoxy)pyridine Hydrochloride (Rabeprazole Chloride Compound) (CAS: 153259-31-5) with high quality, intermediate of Rebeprazole Sodium (CAS: 117976-90-6). Ruifu Chemical offers advanced, high quality pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Rabeprazole Sodium Intermediates, Please contact: alvin@ruifuchem.com

Intermediates of Rabeprazole Sodium:

Rabeprazole Sodium	CAS 117976-90-6
Rabeprazole Hydroxy Compound	CAS 675198-19-3
Rabeprazole Chloride Compound	CAS 153259-31-5

153259-31-5 - Chemical Properties:

Chemical Name	2-Chloromethyl-3-Methyl-4-(3-Methoxypropoxy)pyridine Hydrochloride
Synonyms	Rabeprazole Chloride Compound; Rabeprazole Chloro Compound; Rabeprazole 2-Chloromethyl Impurity; 4-(3-Methoxypropoxy)-2-(Chloromethyl)-3-Methylpyridine Hydrochlorid
CAS Number	153259-31-5
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C11H17Cl2NO2
Molecular Weight	266.16
Melting Point	113.0~115.0℃
COA & MSDS	Available
Origin of Product	Shanghai, China
Shelf Life	24 Months When Properly Stored
Product Categories	Pharmaceutical Intermediates
Brand	Ruifu Chemical

153259-31-5 - Specifications:

Item	Specifications	Results
Appearance	Yellowish to Off-White Crystalline Powder	Off-White Crystalline Powder
Assay / Analysis Method	>99.0% (HPLC)	99.82%
Loss on Drying	<0.50%	0.20%
Water (K.F)	<0.50%	0.17%
Residue on Ignition	<0.20%	0.08%
Any Single Impurity	<0.50%	0.08%
Total Impurities	<0.50%	0.18%
Heavy Metals (as Pb)	<20ppm	<20ppm
Conclusion	The product has been tested and complies with the given specifications
Usage	Intermediate of Rebeprazole Sodium (CAS: 117976-90-6)

153259-31-5 - Synthetic Route:

Rabeprazole Chloride Compound CAS 153259-31-5 Synthetic Route

153259-31-5 - Method of Analysis:

Rabeprazole Chloride Compound (CAS: 153259-31-5) Method of Analysis
1 Test method
1.1 Put the sample on the white paper, observe the appearance, yellowish to off-white crystalline powder.
1.2 Moisture: According to the moisture determination method (the first method of Appendix Ⅷ M of the second part of the Chinese Pharmacopoeia 2010 edition), not more than 0.50%.
1.3 Purity: According to high performance liquid chromatography, determined according to law (Chinese Pharmacopoeia 2010 Edition, Part II Appendix VD).
Chromatographic Conditions:
Column: C18, 200mm×4.6mm, 5um;
Mobile Phase: Triethylamine buffer with pH 4.0 (take 6ml triethylamine in 1000ml water, stir well, use phosphoric acid Adjust pH value to 4.0) : Acetonitrile = 600:400 is mobile phase;
Detection wavelength: 254nm
Flow Rate: 1.0ml/min.
Analysis Method: Take about 30mg of this product, precision weighing, dilute with mobile phase to make a concentration of about 0.3mg/ml, take 20 μl was injected into the high performance liquid chromatography instrument and the chromatogram was recorded. According to the area normalization method, the purity is not less than 99.0%.

153259-31-5 - Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

153259-31-5 - Advantages:

153259-31-5 - FAQ:

153259-31-5 - Application:

2-Chloromethyl-3-Methyl-4-(3-Methoxypropoxy)pyridine Hydrochloride, Rabeprazole Chloride Compound (CAS: 153259-31-5) is an intermediate of Rebeprazole Sodium (CAS: 117976-90-6). Rabeprazole Sodium is a anti-ulcer disease drug belonging to proton pump inhibitor and is the sodium salt form of Rabeprazole. The Japanese company Eisai had successfully developed it for the first time with the trade name being “Bolite”. The function of the proton pump inhibitors is reducing the gastric acid secretion so that the lesion site can be stable in order to achieving the effect of curing gastric and duodenal ulcers and stomach-esophageal reflux disease. Clinically it is majorly used for the treatment of acid-related diseases such as stomach and duodenal ulcers, peptic ulcer, gastroesophageal reflux disease and zollinger-ellison syndrome. Rabeprazole is a kind of benzimidazole-substituted compounds. It inhibits the secretion of gastric acid through forming bond with the cytoplasmic proton pump in the gastric cavity wall. This product can specifically inhibit the effect of the adenosine triphosphatase that is the key enzyme during the production of stomach acid. It has inhibitory effect on both basal gastric acid and the gastric acid secretion caused by the stimulation.