L-Thyroxine CAS 51-48-9 Purity >98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of L-Thyroxine (CAS: 51-48-9) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in this product, please send detailed information includes CAS number, product name, quantity to us. Please contact: alvin@ruifuchem.com
| Chemical Name | L-Thyroxine |
| Synonyms | Levothyroxine; L-T4; NSC 36397; (-)-Thyroxine; 3,3',5,5'-Tetraiodo-L-Thyronine; 3,5,3’,5’-Tetraiodothyronine; beta-[(3,5-Diiodo-4-Hydroxyphenoxy)-3,5-Diiodophenyl]alanine; β-((3,5-Diiodo-4-Hydroxyphenoxy)-3,5-Diiodophenyl)alanine; o-(4-Hydroxy-3,5-Diiodophenyl)-3,5-Diiodo-L-Tyrosine |
| CAS Number | 51-48-9 |
| CAT Number | RF2891 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C15H11I4NO4 |
| Molecular Weight | 776.87 |
| Melting Point | 227.0~230.0℃ |
| Boiling Point | 576.3±50.0℃ |
| Density | 2.635 |
| Sensitive | Light Sensitive |
| Water Solubility | Insoluble in Water |
| Solubility | Dissolves in 4M Ammonium Hydroxide in Methanol at 50mg/ml |
| Stability | ≥ 2 Years |
| HS Code | 29379000 |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White or Off-White Crystalline Powder |
| Purity / Analysis Method | >98.0% (HPLC) |
| Melting Point | 227.0~230.0℃ |
| Specific Rotation [α]20/D | -5.2°~ -6.2° (C=1, Ethanol: 1N NaOH=2:1) |
| Heavy Metals (Pb) | ≤10ppm |
| Loss on Drying | <0.20% |
| Residue on Ignition | <0.10% |
| Total Impurities | <1.50% |
| Infrared Spectrum | Conforms to Structure |
| Test Standard | Enterprise Standard |
| Usage | Pharmaceutical Intermediates |
Package: Bottle, Aluminum foil bag, 25kg/Cardboard Drum, or according to customer's requirement
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
L-Thyroxine (CAS: 51-48-9) or Levothyroxine is a synthetic thyroid hormonethat is chemically identical to thyroxine (T4), which is naturally secreted by the follicular cells of the thyroid gland. It is used to treatthyroid hormone deficiency, and occasionally to prevent the recurrence of thyroid cancer. Like its naturally secreted counterpart, Levothyroxine is a chiral compound in the L-form. The related drug dextrothyroxine (D-Thyroxine) was used in the past as a treatment for hypercholesterolemia (elevated cholesterol levels) but was withdrawn due to cardiac side effects. L-Thyroxine is mainly used for the treatment of hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema coma, and stupor. In vivo, L-Thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone from the anterior pituitary in mice. Formulations containing L-Thyroxine have been used in the treatment of hypothyroidism. Levothyroxine therapy is used in case of deficiency of the thyroid hormones in the human organism, as it happens under deficiency of thyroid, pituitary and hypothalamic glands (respectively primary, secondary and tertiary hypothyroidism). L-Thyroxine is also used in the treatment of euthyroid goiter and multinodular goiter, including thyroid nodules, subacute or chronic thyroiditis, or in the case of a post-surgical deficit, or after radiometabolic treatment in patients with thyroid cancer. Effects of this drug depend heavily on dosage. In small doses, L-Thyroxine exhibits anabolic action. In medium doses, it stimulates growth and development of tissue, metabolism of protein, fats, and carbohydrates, increases functional activity of central nervous and cardiovascular systems, as well as kidneys and liver. In large doses, it slows the thyrotropic activity of the hypophysis and suppresses thyroid gland production.
