H-Gly-OtBu·HCl CAS 27532-96-3 Glycine tert-Butyl Ester Hydrochloride Assay 98.0~102.0%

Short Description:

Glycine tert-Butyl Ester Hydrochloride

Synonyms: H-Gly-OtBu·HCl

CAS: 27532-96-3

Assay: 98.0~102.0% (Titration by AgNO3)

Appearance: White Crystalline Powder

Amino Acids and Derivatives, High Quality

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Glycine tert-Butyl Ester Hydrochloride (H-Gly-OtBu·HCl) (CAS: 27532-96-3) with high quality. Ruifu Chemical supplys a series of amino acids and derivatives. We can provide worldwide delivery, small and bulk quantities available. Purchase H-Gly-OtBu·HCl, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	Glycine tert-Butyl Ester Hydrochloride
Synonyms	H-Gly-OtBu·HCl; Gly-OtBu·HCl; Glycine t-Butyl Ester Hydrochloride; Glycine tert-Butyl Ester HCl; tert-Butyl Glycinate Hydrochloride
Stock Status	In Stock, Production Capacity 35 Tons per Month
CAS Number	27532-96-3
Molecular Formula	C6H13NO2·HCl
Molecular Weight	167.63 g/mol
Melting Point	141.0~143.0℃(lit.)
Sensitive	Hygroscopic
Solubility	Soluble in Methanol and Water
Storage Temp.	Cool & Dry Place (2~8℃)
COA & MSDS	Available
Category	Amino Acids and Derivatives
Brand	Ruifu Chemical

Specifications:

Items	Inspection Standards	Results
Appearance	White Crystalline Powder	Complies
Melting Point	141.0~143.0℃	141.0~142.0℃
Loss on Drying	<0.50%	0.36%
Heavy Metals (Pb)	≤10ppm	<10ppm
Glycine (Gly)	≤0.10% (TLC)	<0.10%
H-Gly-OtBu·HCl Assay	98.0~102.0% (Titration by AgNO3)	99.36%
Infrared Spectrum	Conforms to Structure	Complies
Proton NMR Spectrum	Conforms to Structure	Complies
Solubility in H2O 50mg/ml (5%)	Colorless, Clear to Very Slightly Hazy	Pass
Conclusion	The product has been tested & complies with the given specifications

Package & Storage:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

27532-96-3 - Risk and Safety:

Risk Codes 36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description 24/25 - Avoid contact with skin and eyes.
WGK Germany 3
FLUKA BRAND F CODES 10-23
TSCA No
HS Code 2922491990

Application:

Glycine tert-Butyl Ester Hydrochloride (H-Gly-OtBu·HCl) (CAS: 27532-96-3) is not only an important chemical raw material, but also widely used in drug synthesis and has good development prospects.
Amino acids and derivatives, used in peptide synthesis, organic synthesis intermediates, pharmaceutical intermediates, biochemical reagents, chemical reagents.
Preparation 1400L t-Butyl Acetate, 105KG Glycine and 180KG Perchloric Acid were added dropwise at a uniform speed in a 2000L reaction tank. React at 0-10℃ for about 48-72 hours. TLC monitors the reaction during the reaction. After the glycine reaction is more than 90%, use 4 N sodium hydroxide aqueous solution to adjust the PH 6.5-7.5 to separate the organic layer. The water layer continues to be extracted with tert-Butyl Acetate. After the water product is basically extracted to the 95%, all product layers are combined, washed with brine to TLC purity to obtain 1500L tert-Butyl Glycine/tert-Butyl Ethyl Ester solution, concentrate and recover tert-Butyl Ethyl Ester to obtain 180KG of tert-Butyl Glycine, add 100L of Ethyl Ethyl Ester, pass hydrogen chloride to PH0.5, stir and cool the cold crystal, and centrifugally wash to obtain 182KG of tert-Butyl Glycine Hydrochloride.