DAPT (GSI-IX) CAS 208255-80-5 γ-Secretase Inhibitor Assay >98.0% (HPLC) Factory
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of DAPT (GSI-IX) (CAS: 208255-80-5) with high quality, γ-Secretase Inhibitor. Ruifu Chemical supplys a series of amino acids and derivatives. We can provide worldwide delivery, small and bulk quantities available. Purchase DAPT, Please contact: alvin@ruifuchem.com
| Chemical Name | DAPT |
| Synonyms | GSI-IX; γ-Secretase Inhibitor IX; gamma-Secretase Inhibitor; LY-374973; (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu; (3,5-Difluorophenylacetyl)-L-Alanyl-L-2-Phenylglycine tert-Butyl Ester; N-[N-(3,5-Difluorophenacetyl)-L-Alanyl]-S-Phenylglycine t-Butyl Ester; (2S)-N-[2-(3,5-Difluorophenyl)acetyl]-L-Alanyl-2-Phenyl-glycine 1,1-Dimethylethyl Ester |
| Stock Status | In Stock |
| CAS Number | 208255-80-5 |
| Molecular Formula | C23H26F2N2O4 |
| Molecular Weight | 432.47 |
| Density | 1.213 g/cm3 |
| Melting Point | 142.0~146.0℃ |
| Sensitive | Heat Sensitive |
| Solubility | Soluble in DMSO |
| Storage Temp. | Store at 2-8℃ |
| COA & MSDS | Available |
| Brand | Ruifu Chemical |
| Safety Statements | 24/25 - Avoid contact with skin and eyes. | ||
| WGK Germany | 3 | HS Code | 2922491990 |
| Items | Inspection Standards | Results |
| Appearance | White or Off-White Crystalline Powder | Conforms |
| Loss on Drying | <0.40% | 0.21% |
| Residue on Ignition | <0.40% | 0.20% |
| Heavy Metals (as Pb) | ≤20ppm | <20ppm |
| Assay / Analysis Method | >98.0% (HPLC) | 98.62% |
| Carbon by Elemental Analysis | 62.1~64.1% | Conforms |
| Nitrogen by Elemental Analysis | 6.20~6.70% | Conforms |
| Infrared Spectrum | Conforms to Structure | Conforms |
| NMR Spectrum | Conforms to Structure | Conforms |
| Conclusion | This Product by Inspection Accords with the Enterprise Standard | |
| Shelf Life | 24 Months From Manufacture Date if Stored Properly | |
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool, dry (store at 2-8℃) and ventilated warehouse away from incompatible substances. Protect from light and moisture.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
DAPT (GSI-IX) (CAS: 208255-80-5), a potent and specific inhibitor of γ-secretase. DAPT is an inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically). Oral administration of DAPT has been shown to reduce levels of Aβ in brain extract, cerebrospinal fluid and plasma from mice and rats. DAPT blocks Notch signaling which promotes neuronal differentiation of precursor cells. Enhances iPS cells without oncogenes KLF4 and CMYC5. Cell permeable. DAPT is used in the study of β-amyloid formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus, as well as in cancer cell growth, angiogenesis, and differentiation of human induced pluripotent stem cells. Inhibits Notch signalling in vitro. Inhibits total Aβ and Aβ42 production in human primary cultures (IC50 values are 115 and 200 nM, respectively) with no effect on APPα and APPβ levels. Blood-brain barrier permeable. 3D Growth matrix component and component of cerebral organoid differentiation media.
