D-Prolinol CAS 68832-13-3 Purity >99.0% (GC) E.E >99.0% Factory High Quality
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of D-Prolinol (CAS: 68832-13-3) with high quality. Ruifu Chemical supply a series of amino acids derivatives and peptide synthesis reagents. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in D-Prolinol, Please contact: alvin@ruifuchem.com
| Chemical Name | D-Prolinol |
| Synonyms | D(-)Prolinol; (R)-Prolinol; (R)-(-)-Prolinol; (R)-(-)-2-(Hydroxymethyl)pyrrolidine; (R)-(-)-2-Pyrrolidinemethanol; (R)-Pyrrolidin-2-Methanol; (R)-1-Pyrrolidin-2-ylmethanol; H-D-Pro-ol |
| Stock Status | In Stock, Production Capacity 50 Tons per Month |
| CAS Number | 68832-13-3 |
| Molecular Formula | C5H11NO |
| Molecular Weight | 101.15 |
| Boiling Point | 74.0~76.0℃/2 mm Hg(lit.) |
| Flash Point | 86℃(186°F) |
| Sensitive | Hygroscopic. Air Sensitive, Moisture Sensitive, Heat Sensitive |
| Water Solubility | Completely Soluble in Water |
| Solubility | Very Soluble in Alcohol |
| Storage Temp. | Sealed in Dry, Room Temperature |
| COA & MSDS | Available |
| Brand | Ruifu Chemical |
| Hazard Codes | Xi | F | 3-10-23 |
| Risk Statements | 36/37/38 | Hazard Note | Irritant/Air Sensitive |
| Safety Statements | 26-36-24/25-26/36 | Hazard Class | IRRITANT |
| RIDADR | NA 1993 / PGIII | HS Code | 2922199090 |
| WGK Germany | 3 |
|
Item |
Inspection Standard |
Results |
|
Appearance |
Colorless Transparent Liquid |
Conforms |
|
D-Prolinol Purity |
>99.0% (GC) |
99.61% |
|
Boiling Point |
74.0~76℃ |
Conforms |
|
Specific Rotation [α]20/D |
-33.0° to -29.0°（C=1, C7H8） |
-31.0° |
|
E.E |
>99.0% |
99.90% |
|
Water (K.F) |
<0.50% |
0.33% |
|
Refractive Index n20/D |
1.483~1.490 |
Conforms |
|
Density (20°C) |
1.035~1.040 |
Conforms |
|
Infrared Spectrum |
Conforms to Structure |
Conforms |
|
Conclusion |
This Product by Inspection Accords with the Enterprise Standard | |
|
Main Usage |
Chiral Amino Alcohols; Chiral Resolving Agents | |
Package: Fluorinated Bottle, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
D-Prolinol (CAS: 68832-13-3), the D-enantiomer of prolinol, is a chiral amino alcohol used as a chiral resolver in organic synthesis. In recent years, with the rapid development of asymmetric catalysis technology, D-Prolinol has become an excellent ligand for metal coordination catalysis, widely used in asymmetric metal alkylation reaction, Michael addition reaction, phase transfer catalysis and other important organic synthesis. D-Prolinol makes use of an intermediate of pharmaceuticals.
Synthesis methods: There are two main methods for the synthesis of D-Prolinol: (1) Indirect reduction method: taking D-Proline as raw material, esterification, neutralization, and then reduction with NaBH4; (2) Direct reduction method: D-Proline was directly reduced by AlLiH4. The former process is complicated and the yield is low (42.6%). The latter operation is harsh, low temperature ice bath drops, high cost, deep product color. The author directly reduced D-proline to D-prolinol by using the reduction system of NaBH4 additive I2 (see the figure below), which has low cost, good quality, stable process, simple operation and easy industrialization.
