2-Amino-3-Benzoyl-α-(Methylthio)benzeneacetamide CAS 78281-61-5 Nepafenac Intermediate

Short Description:

2-Amino-3-Benzoyl-α-(Methylthio)benzeneacetamide 

CAS: 78281-61-5

Purity: 99.0 to 101.0% 

Appearance: Yellow Powder

Intermediate of Nepafenac (CAS: 78281-72-8) 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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78281-61-5 - Description:

Ruifu Chemical is the leading manufacturer of 2-Amino-3-Benzoyl-α-(Methylthio)benzeneacetamide (CAS: 78281-61-5) with high quality, intermediate of Nepafenac (CAS: 78281-72-8). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Nepafenac intermediates, Please contact: alvin@ruifuchem.com

78281-61-5 - Chemical Properties:

Chemical Name 2-Amino-3-Benzoyl-α-(Methylthio)benzeneacetamide
Synonyms 2-Amino-3-Benzoyl-alpha-(Methylthio)benzeneacetamide; 2-(2-Amino-3-Benzoylphenyl)-2-(Methylthio)acetamide; 2-Amino-3-Benzoly-α-Methylthio-Phenylacetamide; Nepafenac Impurity 1; Nepafenac Methylthio Impurity
Stock Status In Stock, Commercial Production  
CAS Number 78281-61-5
Molecular Formula C16H16N2O2S
Molecular Weight 300.38 g/mol
Melting Point 153.0~155.0℃ 
Density 1.280±0.06 g/cm3 
COA & MSDS Available
Place of Origin  Shanghai, China
Brand Ruifu Chemical

78281-61-5 - Specifications:

Items Specifications  Results
Appearance Yellow Powder  Yellow Powder    
Loss on Drying <1.00% 0.41% 
TLC Analysis One Spot One Spot
NMR Spectrum Consistent with Structure Complies 
Purity / Analysis Method 99.0 to 101.0% (HPLC)  99.98% 
Conclusion The product has been tested and complies with the given specifications

Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

78281-61-5 - Application:

2-Amino-3-Benzoyl-α-(Methylthio)benzeneacetamide (CAS: 78281-61-5), intermediate of Nepafenac (CAS: 78281-72-8). Nepafenac is a non-steroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop. It reduces pain and inflammation in the eyes. Nepafenac ophthalmic is used to reduce pain and swelling after cataract surgery. Compared with traditional NSAIDs, chemical structure of Nepafenac is conducive to make it rapidly penetrate the cornea and distribute to its target site, which is helpful to reduce the accumulation of the drug in the corneal surface and to reduce the incidence of complications of the eye surface, it has many advantages such as infiltration, targeting strong, little toxic side effects and so on.

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