5-Bromo-2-Chloro-4′-Ethoxydiphenylmethane CAS 461432-23-5 Dapagliflozin Intermediate
Manufacturer Supply, High Purity, Commercial Production
Dapagliflozin (CAS: 461432-26-8) Related Intermediates:
5-Bromo-2-Chlorobenzoic Acid CAS 21739-92-4
5-Bromo-2-Chloro-4'-Ethoxydiphenylmethane CAS 461432-23-5
2,3,4,6-Tetrakis-O-Trimethylsilyl-D-Gluconolactone CAS 32384-65-9
| Chemical Name | 5-Bromo-2-Chloro-4'-Ethoxydiphenylmethane |
| Synonyms | 4-Bromo-1-Chloro-2-(4-Ethoxybenzyl)benzene; 4-(5-Brom-2-Chlorbenzyl)phenyl-Ethylether; Dapagliflozin Bromo Impurity |
| CAS Number | 461432-23-5 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C15H14BrClO |
| Molecular Weight | 325.63 |
| Melting Point | 41.0 to 43.0℃ |
| Density | 1.371±0.06 g/cm3 |
| COA & MSDS | Available |
| Place of Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Item | Specifications | Results |
| Appearance | White to Pael Yellow Crystalline Powder | Conforms |
| Purity / Analysis Method | ≥98.0% (HPLC) | 98.91% |
| Water (K.F) | ≤0.50% | 0.15% |
| Infrared Spectrum | Conforms to Structure | Conforms |
| 1 H NMR Spectrum | Conforms to Structure | Conforms |
| Test Standard | Enterprise Standard | Conforms |
| Application | Intermediate of Dapagliflozin (CAS: 461432-26-8), type II diabetes | |
Package: Bottle, Aluminium foil bag, Cardboard Drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.
4-Bromo-1-Chloro-2-(4-Ethoxybenzyl)benzene (CAS: 461432-23-5) is used as a intermediate in the synthesis of Dapagliflozin (CAS: 461432-26-8). Dapagliflozin is a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. Dapagliflozin is a new antidiabetic drug jointly developed by Bristol-Myers Squibb and AstraZeneca, being approved by the European Medicines Agency (EMA) on November 12, 2012. On January 8, 2014, the US Food and Drug Administration (FDA) have approved it for being used in the treatment of type II diabetes.
