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2021 New Style Ropivacaine Hydrochloride Monohydrate - Luliconazole CAS 187164-19-8 Purity ≥99.0% HPLC Factory API High Quality – Ruifu Featured Image
  • 2021 New Style Ropivacaine Hydrochloride Monohydrate - Luliconazole CAS 187164-19-8 Purity ≥99.0% HPLC Factory API High Quality – Ruifu

2021 New Style Ropivacaine Hydrochloride Monohydrate - Luliconazole CAS 187164-19-8 Purity ≥99.0% HPLC Factory API High Quality – Ruifu

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2021 New Style Ropivacaine Hydrochloride Monohydrate - Luliconazole CAS 187164-19-8 Purity ≥99.0% HPLC Factory API High Quality – Ruifu Detail:

Supply Luliconazole and Related Intermediates
Luliconazole CAS 187164-19-8
(1-Imidazolyl)acetonitrile CAS 98873-55-3
(S)-2,4-Dichloro-α-(Chloromethyl)benzyl Alcohol CAS 126534-31-4

Chemical Name Luliconazole
Synonyms (2E)-2-[(4R)-4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-(1H-imidazol-1-yl)acetonitrile; NND 502
CAS Number 187164-19-8
CAT Number RF-API110
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C14H9Cl2N3S2
Molecular Weight 354.27
Melting Point 150.0 to 154.0℃
Specific Rotation [a]20/D -48.0° to -53.0° (C=1, DMF)
Solubility Insoluble in Water; Soluble in Acetone; Slightly Soluble in Methanol
Brand Ruifu Chemical
Item Specifications
Appearance Off-White to Light Yellow Crystalline Powder
Identification IR The infrared spectrum of the sample should correspond to that of the reference standard
Identification HPLC The retention time of the major peak of the sample solution should correspond to that of the standard solution as obtained in the test
Loss on Drying ≤0.50%
Residue on Ignition ≤0.20%
Heavy Metals (Pb) ≤20ppm
Related Substances
Any Individual Impurity ≤0.20%
Total Impurities ≤0.50%
Residual Solvents
Methanol ≤3000ppm
Acetonitrile ≤410ppm
Dichloromethane ≤600ppm
N-Hexane ≤290ppm
Ethyl Acetate ≤5000ppm
Tetrahydrofuran ≤720ppm
Methyl tert-Butyl Ether ≤5000ppm
N-Heptane ≤5000ppm
Triethylamine ≤320ppm
Dimethyl Sulfoxide ≤5000ppm
Purity / Analysis Method ≥99.0% (HPLC) (on the dried basis)
Test Standard Enterprise Standard
Usage Pharmaceutical Intermediates

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.

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Luliconazole (CAS: 187164-19-8) is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole is a kind of analogue of lanoconazole. It can interfere with the fungal cell wall synthesis and fungal growth by decreasing levels of ergosterol via inhibiting lanosterol demethylase activity. Besides being used for the treatment of athlete’s foot, jock itch and ringworm, it has also been developed for onychomycosis (nail fungus) treatment and has now also entered the clinical stage phase III. This product was originally developed by the Japanese pesticide Corporation (NihonNohyaku Co., Ltd.). In November 2013, the FDA has approved a 1% luliconazole cream for entering into market for topical treatment of interdigital athlete’s foot, jock itch and ringworm with the trade name being Luzu and first entered into market in North America. As early as April 2005, luliconazole had been approved to enter into market in Japan under the trade name Lulicon. In January 2010 and June 2012, it was approved for marketing in India and China, respectively.

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