2021 Good Quality Methyl 5-bromo-6-chloropyridine-3-carboxylate - 4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate CAS 327-78-6 Purity ≥99.0% Sorafenib Tosylate Intermediate – Ruifu

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2021 Good Quality Methyl 5-bromo-6-chloropyridine-3-carboxylate - 4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate CAS 327-78-6 Purity ≥99.0% Sorafenib Tosylate Intermediate – Ruifu Detail:

Manufacturer with High Purity and Stable Quality
Commercial Supply Sorafenib Tosylate (CAS: 475207-59-1) Related Intermediates:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4-(4-Aminophenoxy)-N-Methyl-2-Pyridinecarboxamide CAS: 284462-37-9
4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate CAS: 327-78-6

Name	4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate
Synonyms	Isocyanic Acid 4-Chloro-3-(Trifluoromethyl)phenyl Ester
CAS Number	327-78-6
CAT Number	RF-PI167
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C8H3ClF3NO
Molecular Weight	221.56
Brand	Ruifu Chemical

Item	Specifications
Appearance	White Crystalline
Purity / Analysis Method	≥99.0% (HPLC)
Identification	(1) IR (2) HPLC
Moisture (K.F)	≤0.50%
Heavy Metals	≤10ppm
Impurity A	≤0.15%
Impurity B	≤1.0%
Impurity C	≤1.0%
Other Single Impurity	≤0.50%
Total Impurities	≤2.0%
Test Standard	Enterprise Standard
Usage	Intermediate of Sorafenib Tosylate (CAS: 475207-59-1)

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Sorafenib Tosylate (CAS: 475207-59-1) is a new type of multi-target antitumor drug, was developed by the German Bayer Pharmaceuticals, and displayed expansive antitumor activity in preclinical animal tests. Sorafenib is available in 200-mg tablets for oral administrationand is used in the treatment of RCC and HCC. Sorafenib Tosylate (CAS: 475207-59-1) can simultaneously affect tumor cells and tumor blood vessels. It has a double antitumor effect: it can block the cell signal transduction pathways mediated by RAF/MEK/ERK to directly inhibit tumor cell growth, while also inhibiting VEGF and platelet derived growth factors (PDGF) receptors to prevent the formation of new tumor blood vessels, thus indirectly inhibiting tumor cell growth. Sorafenib Tosylate (Bay 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.

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